In vaccination programmes in which large numbers of subjects are involved, the oral route of
administration is more convenient as compared to the more frequently used parenteral route…

TLR3 recognizes dsRNAs and is considered of key importance to antiviral host-defense
responses. TLR3 also triggers neuroprotective responses in astrocytes and controls the growth …

Phenotypic assays using human primary cells are highly valuable tools for target discovery
and validation in drug discovery. Expression knockdown (KD) of such targets in these assays …

The structure of the crystallisation domain, SAN, of the S A -protein of Lactobacillus acidophilus
ATCC 4356 was analysed by insertion and deletion mutagenesis, and by proteolytic …

Background: Probiotic bacteria may render mice resistant to the development of various
inflammatory and infectious diseases. Objective: This study aimed to identify mechanisms by …

Publisher Summary This chapter discusses lactobacilli as vehicles for targeting antigens to
mucosal tissues by surfaces exposition for foreign antigens. Lactobacillus strains have a …

VSL#3, a mixture of 8 different probiotic bacteria, has successfully been used in the clinic to
treat Ulcerative Colitis. We previously identified the modulation of chemokines as a major …

The effect of vitamin A deficiency on the mitogen response of splenic B and T lymphocytes
was determined in adult vitamin A-deficient rats. Female weanling Brown Norway/Billingham-…

The experimental autoimmune encephalomyelitis model is a model of multiple sclerosis that
closely mimics the disease characteristics in humans. The main hallmarks of multiple …

A new method of thymus transplantation is introduced, in which the graft is directly connected
with the recipient's vascular system. This procedure was used both in euthymic rats and …