Tumor of the ampulla of Vater: experience with local or radical resection in 171 consecutively treated patients

HG Beger, F Treitschke, F Gansauge… - Archives of …, 1999 - jamanetwork.com
Hypothesis This study was designed to evaluate prospectively oncological factors determining
survival after resection of tumors of the papilla, comparing local and radical oncological …

Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis

S Gansauge, F Gansauge, M Ramadani, H Stobbe… - Cancer research, 1997 - AACR
We have investigated the expression of cyclin D1 in adenocarcinoma of the pancreas and
the relevance of cyclin D1 expression to clinical outcome. In comparison to normal pancreas, …

Treatment of pancreatic cancer: challenge of the facts

HG Beger, B Rau, F Gansauge, B Poch, KH Link - World journal of surgery, 2003 - Springer
Adenocarcinoma of the pancreas is associated with the worst survival of any form of
gastrointestinal malignancy. In spite of the progress in surgical treatment, resulting in increasing …

Glutathione depletion causes cell growth inhibition and enhanced apoptosis in pancreatic cancer cells

…, S Gansauge, F Gansauge… - … Journal of the …, 2000 - Wiley Online Library
BACKGROUND Recent studies have demonstrated that various tumors express enhanced
levels of the radical scavenger glutathione (GSH). Moreover, there are grounds for claiming …

[PDF][PDF] Overexpression of glucose transporter 1 and increased FDG uptake in pancreatic carcinoma

…, M Port, M Hildebrandt, F Gansauge… - Journal of Nuclear …, 1997 - Soc Nuclear Med
Increased glycolysis is a characteristic metabolic feature of a malig nant transformed phenotype.
In cultured cells transformed by vi ruses or activated oncogenes, enhanced glycolytic …

Pathophysiologic role of oxygen free radicals in acute pancreatitis: initiating event or mediator of tissue damage?

B Rau, B Poch, F Gansauge, A Bauer… - Annals of …, 2000 - journals.lww.com
Materials and Methods Two hundred male Wistar rats were randomly assigned to one of the
following experimental groups. In two groups, acute necrotizing pancreatitis was induced by …

Regulation of Cell Growth and Cyclin D1 Expression by the Constitutively Active FRAP-p70s6K Pathway in Human Pancreatic Cancer Cells

M Grewe, F Gansauge, RM Schmid, G Adler… - Cancer research, 1999 - AACR
The FRAP-p70 s6K signaling pathway was found to be constitutively phosphorylated/active
in MiaPaCa-2 and Panc-1 human pancreatic cancer cells and a pancreatic cancer tissue …

Biglycan is overexpressed in pancreatic cancer and induces G1-arrest in pancreatic cancer cell lines

…, P Michl, H Fensterer, M Weimer, F Gansauge… - Gastroenterology, 2001 - Elsevier
Background & Aims: Biglycan (PG-I), a component of the extracellular matrix (ECM), is
overexpressed in pancreatic cancer. To determine possible matrix-tumor interactions, we …

[HTML][HTML] The role of polymorphonuclear leukocytes and oxygen-derived free radicals in experimental acute pancreatitis: mediators of local destruction and activators of …

B Poch, F Gansauge, B Rau, U Wittel, S Gansauge… - FEBS letters, 1999 - Elsevier
Using a retrograde infusion sodium taurocholate pancreatitis model in the rat treatment with
oxygen radical scavengers or monoclonal anti-ICAM-1 antibody decreased tissue damage …

Increased angiogenin expression in pancreatic cancer is related to cancer aggressiveness

S Shimoyama, F Gansauge, S Gansauge, G Negri… - Cancer research, 1996 - AACR
We have investigated the expression of angiogenin (ANG) in pancreatic cancer and the
relevance of ANG expression to the progression of pancreatic cancer. In comparison to normal …