Patterns of cell death have been divided into apoptosis, which is actively executed by specific
proteases, the caspases, and accidental necrosis. However, there is now accumulating …

Fanconi anaemia (FA) is an autosomal recessive disorder characterized by a diversity of
clinical symptoms including skeletal abnormalities, progressive bone marrow failure and a …

Recent knowledge on apoptosis has made it possible to devise novel approaches, which
exploit this process to treat cancer. In this review, we discuss in detail approaches to induce …

The epidermal growth factor receptor (EGFR) is an important novel target for anticancer therapy.
In this study, we examined the molecular mechanisms that underlie the antitumor effects …

Purpose Epigenetic modifications may contribute to the development and progression of
cancer. We investigated whether epigenetic changes involving multiple histones influence …

Glioblastoma (GBM) is the most common brain tumor in adults and the mesenchymal GBM
subtype was reported to be the most malignant, presenting severe hypoxia and necrosis. Here…

We have previously reported that the microtubule stabilizing agents (MSAs) paclitaxel,
epothilone B and discodermolide induce caspase-independent cell death in non-small cell lung …

Chemotherapy-induced apoptosis is generally thought to be dependent on a pathway
headed by caspase-9. This model is primarily based on studies performed in leukemia cells; …

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors are promising
targets for the selective eradication of tumor cells while sparing normal cells. Currently, both …

Different molecular subtypes of glioblastoma (GBM) have been recently identified, of which
the mesenchymal subtype is associated with worst prognoses. Here, we report that …