Bioactive IL-18 expression is up-regulated in Crohn's disease

…, R Iuliano, F Luzza, A Fusco, F Pallone - The Journal of …, 1999 - journals.aai.org
An imbalance of immunoregulatory factors is believed to contribute to uncontrolled mucosal
Th1 cell activation in Crohn’s disease (CD). IL-18, a macrophage-like cell-derived cytokine, …

Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells

…, G Morrone, O Marasco, F Luzza, F Pallone - Gastroenterology, 1997 - Elsevier
BACKGROUND & AIMS: Cell-mediated immunity is a feature of Crohn's disease (CD). The
heterodimer interleukin (IL)-12, produced by phagocytes, induces T-cell cytokines, primarily …

Cutting edge: TGF-β induces a regulatory phenotype in CD4+ CD25− T cells through Foxp3 induction and down-regulation of Smad7

…, C Becker, G Monteleone, F Pallone… - The Journal of …, 2004 - journals.aai.org
CD4+ CD25+ regulatory cells are a subpopulation of T lymphocytes of thymic origin.
However, recent data suggest an alternative commitment of regulatory T cells in the periphery, …

Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosa

…, M Romano, R Zarrilli, M Imeneo, F Pallone - The Journal of …, 2000 - journals.aai.org
Helicobacter pylori (Hp)-associated gastritis is characterized by an increased number of acute
and chronic inflammatory cells secreting cytokines that contribute to maintain and expand …

Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract

…, G Sica, P Sileri, L Biancone, TT MacDonald, F Pallone… - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: The pathogenesis of inflammatory bowel disease (IBD) is believed
to involve an altered balance between effector and regulatory T cells. Aryl hydrocarbon …

[HTML][HTML] Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn's Disease

…, V Savarino, R Pica, A Orlando, F Pallone - … England Journal of …, 2015 - Mass Medical Soc
Background Crohn’s disease–related inflammation is characterized by reduced activity of the
immunosuppressive cytokine transforming growth factor β1 (TGF-β1) due to high levels of …

Interleukin-21 enhances T-helper cell type I signaling and interferon-γ production in Crohn's disease

…, L Biancone, GC Naccari, TT MacDonald, F Pallone - Gastroenterology, 2005 - Elsevier
Background & Aims T-helper (Th)1 cells play a central role in the pathogenesis of tissue
damage in Crohn’s disease (CD). Interleukin (IL)-12/STAT4 signaling promotes Th1 cell …

IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes

…, M Boirivant, TT MacDonald, F Pallone… - The Journal of …, 2007 - journals.aai.org
High expression of IL-21 and/or IL-21R has been described in T cell-mediated inflammatory
diseases characterized by defects of counterregulatory mechanisms. CD4+ CD25+ …

Il-23/Il-17 Axis in IBD

M Sarra, F Pallone, TT MacDonald… - Inflammatory bowel …, 2010 - academic.oup.com
Gut inflammation occurring in patients with Crohn's disease and patients with ulcerative
colitis has been traditionally associated with an exaggerated Th1 or Th2 cell response, …

Regulation of gut inflammation and th17 cell response by interleukin-21

…, C Stolfi, I Cardolini, M Dottori, M Boirivant, F Pallone… - Gastroenterology, 2008 - Elsevier
Background & Aims: Interleukin (IL)-21, a T-cell-derived cytokine, is overproduced in
inflammatory bowel diseases (IBD), but its role in the pathogenesis of gut inflammation remains …