Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation

…, F Dollé, B Kuhnast, F Hinnen… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Overexpression of the translocator protein, TSPO (18 kDa), formerly known as the peripheral
benzodiazepine receptor, is a hallmark of activation of cells of monocytic lineage (microglia …

Decreased presynaptic dopamine function in the left caudate of depressed patients with affective flattening and psychomotor retardation

…, E Artiges, F Dollé, F Hinnen… - American Journal of …, 2001 - Am Psychiatric Assoc
OBJECTIVE: The study assessed striatal presynaptic dopamine function in patients with
different subtypes of depression. METHOD: Magnetic resonance imaging and positron emission …

In vivo imaging of oligonucleotides with positron emission tomography

…, F Dollé, JR Deverre, A Jobert, F Hinnen… - Nature …, 1998 - research.uniupo.it
The data reported in this study show (1) that the proposed radiolabelling methods does not
modify the capcity of the antisense oligonucleotide to hybridize to its target complemetary …

Fluorine-18-Labeled Phospholipid Quantum Dot Micelles for in Vivo Multimodal Imaging from Whole Body to Cellular Scales

…, B Thézé, K Gombert, B Mahler, F Hinnen… - Bioconjugate …, 2008 - ACS Publications
We have designed new nanoprobes applicable for both positron emission tomography (PET)
and optical fluorescence in vivo imaging. Fluorine-18, which is commonly used for clinical …

1-[3-(2-[18F]Fluoropyridin-3-yloxy)propyl]pyrrole-2,5-dione:  Design, Synthesis, and Radiosynthesis of a New [18F]Fluoropyridine-Based Maleimide Reagent for the …

B De Bruin, B Kuhnast, F Hinnen… - Bioconjugate …, 2005 - ACS Publications
FPyME (1-[3-(2-fluoropyridin-3-yloxy)propyl]pyrrole-2,5-dione) was designed as a [ 18 F]fluoropyridine-based
maleimide reagent for the prosthetic labeling of peptides and proteins via …

Synthesis and Nicotinic Acetylcholine Receptor in Vivo Binding Properties of 2-Fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: A New Positron Emission Tomography …

F Dollé, L Dolci, H Valette, F Hinnen… - Journal of medicinal …, 1999 - ACS Publications
The lead compound of a new series of 3-pyridyl ethers, the azetidine derivative A-85380 (3-[(S)-2-azetidinylmethoxy]pyridine),
is a potent and selective ligand for the human α4β2 …

Radiosynthesis of [18F]DPA‐714, a selective radioligand for imaging the translocator protein (18 kDa) with PET

A Damont, F Hinnen, B Kuhnast… - Journal of Labelled …, 2008 - Wiley Online Library
Recently, a novel series of 2‐phenylpyrazolo[1,5‐a]pyrimidineacetamides has been reported
as selective ligands of the translocator protein (18 kDa). Within this series, DPA‐714 (N,N‐…

6‐[18F]Fluoro‐L‐DOPA by radiofluorodestannylation: a short and simple synthesis of a new labelling precursor

F Dolle, S Demphel, F Hinnen… - Journal of Labelled …, 1998 - Wiley Online Library
This paper describes a short and simple synthesis of a new fully protected stannylated
precursor, namely N‐(tert‐butoxycarbonyl)‐3,4‐di(tert‐butoxycarbonyloxy)‐6‐trimethylstannyl‐L‐…

Encapsulated GDNF-producing C2C12 cells for Parkinson's disease: a pre-clinical study in chronic MPTP-treated baboons

…, J Bloch, J Dauguet, F Condé, F Dollé, F Hinnen… - Neurobiology of …, 2004 - Elsevier
Glial cell line-derived neurotrophic factor (GDNF), a potent neurotrophic factor with restorative
effects in a variety of rodent and primate models of Parkinson's disease (PD), could be of …

[18F] DPA-714,[18F] PBR111 and [18F] FEDAA1106—Selective radioligands for imaging TSPO 18 kDa with PET: Automated radiosynthesis on a TRACERLAb FX-FN …

B Kuhnast, A Damont, F Hinnen, T Catarina… - Applied Radiation and …, 2012 - Elsevier
Imaging of TSPO 18kDa with PET is more and more considered as a relevant biomarker of
inflammation in numerous diseases. Development of new radiotracers for TSPO 18kDa has …