Object. Glioblastomas multiforme (GBMs) grow rapidly and are highly resistant to treatment
compared with other glioma types and grades. Consequently, it is of major interest to identify …

Repair of cytotoxic DNA damage by O 6 ‐methylguanine‐DNA methyltransferase (MGMT) is
a potentially important factor of chemoresistance to chloroethylnitrosoureas (CENUs), …

We examined the relevance of a pre-treatment single static view 99mTc-sestamibi
scintimammography and expression of multidrug resistance proteins as predictors of response to …

O6-Methylguanine-DNA methyl transferase (MGMT) in human carcinomas has been
associated with tumor resistance to alkylating agents. The aims of this study were: i) to correlate …

RATIONALE AND OBJECTIVES. The extracellular volume fraction (v) was estimated in leg
rabbit muscles by MRI dynamic longitudinal relaxation rate (R 1) relaxometry to distinguish …

Abstract Because 99mTc-sestamibi (MIBI) appears to be a potent candidate for multidrug
resistance (MDR) evaluation in tumors, its cellular uptake should be similar to that of 3H …

An original 99m Tc-labeling method applied to human lymphocytes is described. This
technique is based on the use of stannous pyrophosphate to reduce sodium pertechnetate. The …

A decrease in the intracellular drug concentration in resistant cells as compared to sensitive
cells is one of the characteristics of the MDR phenotype. P-glycoprotein (Pgp) is thought to …

Background As multidrug resistant (MDR) tumour cells generally exhibit a drug accumulation
deficit, the effects of three prototype modulators and their combinations were investigated …

Reverse transcription–polymerase chain reaction (RT-PCR) is a powerful tool to study gene
expression and is used increasingly in clinical medicine and predictive oncology. We …