Background Invasive candidosis is increasingly prevalent in seriously ill patients. Our aim
was to compare micafungin with liposomal amphotericin B for the treatment of adult patients …

Pseudomonas aeruginosa is a major cause of nosocomial infections. This organism shows
a remarkable capacity to resist antibiotics, either intrinsically (because of constitutive …

Background . Mycograb (NeuTec Pharma) is a human recombinant monoclonal antibody
against heat shock protein 90 that, in laboratory studies, was revealed to have synergy with …

Introduction Altered pharmacokinetics (PK) in critically ill patients can result in insufficient
serum β-lactam concentrations when standard dosages are administered. Previous studies on …

Introduction Sepsis is responsible for important alterations in the pharmacokinetics of
antibiotics. Continuous renal replacement therapy (CRRT), which is commonly used in septic …

Antimicrobial therapy for 428 episodes of bacteremia in an 850-bed university hospital was
prospectively evaluated for 1 year to measure the impact of two factors—blood culture results …

Despite the development of novel antibiotics active against Gram-positive bacteria,
vancomycin generally remains the first treatment, although rapidly achieving concentrations …

Introduction It has been proposed that doses of amikacin of >15 mg/kg should be used in
conditions associated with an increased volume of distribution (V d ), such as severe sepsis …

Objectifs Présenter au clinicien une vue d’ensemble des pathologies liées aux infections à P.
aeruginosa (manifestations cliniques, résistance aux antibiotiques, diagnostic, options …

Introduction: Although β-lactams are considered to have a safe therapeutic profile, neurotoxicity
has been reported. The aim of this study was to assess the association between-lactam …