Conjunctival Melanomas Harbor BRAF and NRAS Mutations and Copy Number Changes Similar to Cutaneous and Mucosal Melanomas

…, E Livingstone, A Sucker, F Grabellus… - Clinical Cancer …, 2013 - AACR
Purpose: Conjunctival melanoma is a rare but potentially deadly tumor of the eye. Despite
effective local therapies, recurrence and metastasis remain frequent. Once the tumor has …

Resection of residual disease in patients with metastatic gastrointestinal stromal tumors responding to treatment with imatinib

…, M De Wit, H Lang, F Grabellus… - … journal of cancer, 2005 - Wiley Online Library
Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the
gastrointestinal tract. Long‐term survival of patients with metastatic disease has only been …

Glucose transporter 1 expression, tumor proliferation, and iodine/glucose uptake in thyroid cancer with emphasis on poorly differentiated thyroid carcinoma

F Grabellus, J Nagarajah, A Bockisch… - Clinical nuclear …, 2012 - journals.lww.com
Purpose: Glucose transporters 1 (GLUT1) facilitates glucose uptake in cancer. An inverse
relationship between I-131 and F-18 fluorodeoxyglucose (FDG) uptake in PET/CT (“flip-flop …

[HTML][HTML] Targeted massively parallel sequencing of angiosarcomas reveals frequent activation of the mitogen activated protein kinase pathway

…, A Sucker, B Schwindenhammer, F Grabellus… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Angiosarcomas are rare malignant mesenchymal tumors of endothelial differentiation. The
clinical behavior is usually aggressive and the prognosis for patients with advanced disease …

A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes

…, G Kurriger, B Yang, F Grabellus… - Proceedings of the …, 2010 - National Acad Sciences
We report a mouse model of multiple osteochondromas (MO), an autosomal dominant
disease in humans, also known as multiple hereditary exostoses (MHE or HME) and …

[HTML][HTML] Diffuse sclerosing variant of papillary thyroid carcinoma: lack of BRAF mutation but occurrence of RET/PTC rearrangements

SY Sheu, S Schwertheim, K Worm, F Grabellus… - Modern Pathology, 2007 - Elsevier
Diffuse sclerosing variant of papillary thyroid carcinoma (PTC) is a rare tumour with a
characteristic morphology as well as a strong preponderance for younger female patients. The …

DOG1 regulates growth and IGFBP5 in gastrointestinal stromal tumors

S Simon, F Grabellus, L Ferrera, L Galietta… - Cancer research, 2013 - AACR
Gastrointestinal stromal tumors (GIST) are characterized by activating mutations of KIT or
platelet-derived growth factor receptor α(PDGFRA), which can be therapeutically targeted by …

Dynamic regulation of MEK/Erks and Akt/GSK-3β in human end-stage heart failure after left ventricular mechanical support: myocardial mechanotransduction …

HA Baba, J Stypmann, F Grabellus… - Cardiovascular …, 2003 - academic.oup.com
Objective: Left ventricular assist devices (LVAD) are used to ‘bridge’ patients with end-stage
heart failure to transplantation. After long-term LVAD support, ventricular function may …

Targeting Bcl-2 family proteins modulates the sensitivity of B-cell lymphoma to rituximab-induced apoptosis

C Stolz, G Hess, PS Hähnel, F Grabellus… - Blood, The Journal …, 2008 - ashpublications.org
The chimeric monoclonal antibody rituximab is the standard of care for patients with B-cell
non-Hodgkin lymphoma (B-NHL). Rituximab mediates complement-dependent cytotoxicity …

Prognostic stratification of metastatic gastroenteropancreatic neuroendocrine neoplasms by 18F-FDG PET: feasibility of a metabolic grading system

…, L Adler, A Sabet, TD Pöppel, F Grabellus… - Journal of Nuclear …, 2014 - Soc Nuclear Med
The tumor proliferation marker, Ki-67 index, is a well-established prognostic marker in
gastroenteropancreatic neuroendocrine neoplasms (NENs). Noninvasive molecular imaging …