An array of cell-surface antigens expressed by human cancers have been identified as
targets for antibody-based therapies. The great majority of these antibodies do not have …

In this study, human T cells were provided with a reactivity against the Lewis-Y (Le Y )
carbohydrate antigen, which is overexpressed on 70% of epithelial-derived tumors, but not …

The Lewis Y (Le y ) antigen is a blood group-related antigen that is expressed in a high
proportion of epithelial cancers (including breast, colon, ovary, and lung cancer) and is an …

In some respects, the EGFR appears to be an attractive target for tumor‐targeted antibody
therapy: it is overexpressed in many types of epithelial tumor and inhibition of signaling often …

Purpose: To determine the in vivo characteristics of huA33, a CDR-grafted humanized
antibody against the A33 antigen, we have conducted an open-label, dose escalation, biopsy-…

Purpose: Monoclonal antibodies and tyrosine kinase inhibitors specific for the epidermal
growth factor receptor (EGFR) have been shown to enhance the effect of external beam …

Purpose: This phase I study explored the biodistribution and pharmacokinetics of the
immunoconjugate CMD-193 [a humanized anti–Lewis Y (Le y ) antibody conjugated with …

PURPOSE: KM871 is a chimeric monoclonal antibody against the ganglioside antigen GD3,
which is highly expressed on melanoma cells. We conducted an open-label, dose …

We report the generation of a chimeric monoclonal antibody (ch806) with specificity for an
epitope on the epidermal growth factor receptor (EGFR) that is different from that targeted by …

Radiolabeling monoclonal antibodies (mAbs) allows the evaluation of biodistribution of
constructs in vivo through gamma camera imaging and also permits quantitation of mAb uptake …