Background Background Activated microglia have a key role in the brain's immune response
to neuronal degeneration. The transition of microglia from the normal resting state to the …

Objective: Patient outcome after traumatic brain injury (TBI) is highly variable. The underlying
pathophysiology of this is poorly understood, but inflammation is potentially an important …

The functions of the resting state networks (RSNs) revealed by functional MRI remain
unclear, but it has seemed possible that networks emerge in parallel with the development of …

[11C](R)PK11195-PET is a marker of activated microglia while [11C]PIB-PET detects raised
amyloid load. Here we studied in vivo the distributions of amyloid load and microglial …

It is widely held that the frontal cortex plays a critical part in certain aspects of spatial and
non‐spatial working memory. One unresolved issue is whether there are functionally distinct …

PET with [ 11 C]-(R)-PK11195 is currently the modality of choice for the in vivo imaging of
microglial activation in the human brain. In this work we devised a supervised clustering …

There is general agreement that, after initial processing in unimodal sensory cortex, the
processing pathways for spoken and written language converge to access verbal meaning. …

A kinetic modeling approach for the quantification of in vivo tracer studies with dynamic
positron emission tomography (PET) is presented. The approach is based on a general …

[11 C](R) PK11195-PET measures upregulation of translocator protein, which is associated
with microglial activation,[11 C] PIB-PET is a marker of amyloid, while [18 F] FDG-PET …

Levodopa-induced dyskinesias (LIDs) are the most common and disabling adverse motor
effect of therapy in Parkinson’s disease (PD) patients. In this study, we investigated …