Elevated levels of peripheral benzodiazepine receptors (PBR) are associated with activated
microglia in their response to inflammation. Hence, PBR imaging in vivo is valuable for …

2-Fluoromethyl analogs of (3-[(2-methyl-1,3-thiazol-4yl)ethynyl]pyridine) were synthesized as
potential ligands for metabotropic glutamate subtype-5 receptors (mGluR5s). One of these, …

Translocator protein 18 kDa (TSPO) is a biomarker of neuroinflammation. [ 11 C]ER176
robustly quantifies TSPO in the human brain with positron emission tomography (PET), …

3-Fluoro-1-((thiazol-4-yl)ethynyl)benzenes constitute an important class of high-affinity
metabotropic glutamate subtype 5 receptor (mGluR5) ligands, some of which have been labeled …

We developed a radioligand, 3-fluoro-5-(2-(2- 18 F-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile
( 18 F-SP203), for metabotropic glutamate subtype 5 (mGluR5) receptors that showed …

Metabotropic glutamate subtype-5 receptors (mGluR5) are implicated in several neuropsychiatric
disorders. Positron emission tomography (PET) with a suitable radioligand may enable …

Translocator protein (TSPO) (18 kDa), formerly called the peripheral benzodiazepine
receptor, is upregulated on activated microglia and macrophages and is, thus, a biomarker of …

As a PET biomarker for inflammation, translocator protein (18 kDa) (TSPO) can be
measured with an 18 F-labeled aryloxyanilide, 18 F-N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-…

The translocator protein 18kDa (TSPO) is expressed in the outer mitochondrial membrane
and is implicated in several functions, including cholesterol transport and steroidogenesis. …

Microwave technology has been very successfully applied to enhance PET radiolabeling
reactions, including one-step nucleophilic radiofluorination reactions with [18F] fluoride ion, so …