Role of the immune system in chronic pain
F Marchand, M Perretti, SB McMahon - Nature Reviews Neuroscience, 2005 - nature.com
During the past two decades, an important focus of pain research has been the study of
chronic pain mechanisms, particularly the processes that lead to the abnormal sensitivity — …
chronic pain mechanisms, particularly the processes that lead to the abnormal sensitivity — …
Immune and glial cell factors as pain mediators and modulators
SB McMahon, WBJ Cafferty, F Marchand - Experimental neurology, 2005 - Elsevier
A decade ago the attention of pain scientists was focused on a small number of molecules
such as prostaglandin and bradykinin as peripheral pain mediators or modulators. These …
such as prostaglandin and bradykinin as peripheral pain mediators or modulators. These …
Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain
…, C Gentry, AA Staniland, F Marchand… - Proceedings of the …, 2007 - National Acad Sciences
A recent major conceptual advance has been the recognition of the importance of immune
system–neuronal interactions in the modulation of brain function, one example of which is …
system–neuronal interactions in the modulation of brain function, one example of which is …
Pathophysiology of peripheral neuropathic pain: immune cells and molecules
MA Thacker, AK Clark, F Marchand… - Anesthesia & …, 2007 - journals.lww.com
Damage to the peripheral nervous system often leads to chronic neuropathic pain characterized
by spontaneous pain and an exaggerated response to painful and/or innocuous stimuli. …
by spontaneous pain and an exaggerated response to painful and/or innocuous stimuli. …
CCL2 is a key mediator of microglia activation in neuropathic pain states
While neuroimmune interactions are increasingly recognized as important in nociceptive
processing, the nature and functional significance of these interactions is not well defined. …
processing, the nature and functional significance of these interactions is not well defined. …
P2X7-dependent release of interleukin-1β and nociception in the spinal cord following lipopolysaccharide
AK Clark, AA Staniland, F Marchand… - Journal of …, 2010 - Soc Neuroscience
The cytokine interleukin-1β (IL-1β) released by spinal microglia in enhanced response states
contributes significantly to neuronal mechanisms of chronic pain. Here we examine the …
contributes significantly to neuronal mechanisms of chronic pain. Here we examine the …
Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions
S Pezet, F Marchand, R D'Mello, J Grist… - Journal of …, 2008 - Soc Neuroscience
Here, we show that phosphatidylinositol 3-kinase (PI3K) is a key player in the establishment
of central sensitization, the spinal cord phenomenon associated with persistent afferent …
of central sensitization, the spinal cord phenomenon associated with persistent afferent …
Effects of Etanercept and Minocycline in a rat model of spinal cord injury
F Marchand, C Tsantoulas, D Singh, J Grist… - European Journal of …, 2009 - Elsevier
Loss of function is usually considered the major consequence of spinal cord injury (SCI).
However, pain severely compromises the quality of life in nearly 70% of SCI patients. The …
However, pain severely compromises the quality of life in nearly 70% of SCI patients. The …
Gabapentin reverses microglial activation in the spinal cord of streptozotocin-induced diabetic rats
R Wodarski, AK Clark, J Grist, F Marchand… - European journal of …, 2009 - Elsevier
Diabetes mellitus is the leading cause of peripheral neuropathy worldwide. Despite this
high level of incidence, underlying mechanisms of the development and maintenance of …
high level of incidence, underlying mechanisms of the development and maintenance of …
Animal models of chemotherapy-evoked painful peripheral neuropathies
N Authier, D Balayssac, F Marchand, B Ling… - …, 2009 - Springer
This review examines recent preclinical research on toxic peripheral neuropathy and potential
therapeutic developments. Chemotherapy-induced peripheral neurotoxicity is a major …
therapeutic developments. Chemotherapy-induced peripheral neurotoxicity is a major …