Role of the immune system in chronic pain

F Marchand, M Perretti, SB McMahon - Nature Reviews Neuroscience, 2005 - nature.com
During the past two decades, an important focus of pain research has been the study of
chronic pain mechanisms, particularly the processes that lead to the abnormal sensitivity — …

Immune and glial cell factors as pain mediators and modulators

SB McMahon, WBJ Cafferty, F Marchand - Experimental neurology, 2005 - Elsevier
A decade ago the attention of pain scientists was focused on a small number of molecules
such as prostaglandin and bradykinin as peripheral pain mediators or modulators. These …

Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain

…, C Gentry, AA Staniland, F Marchand… - Proceedings of the …, 2007 - National Acad Sciences
A recent major conceptual advance has been the recognition of the importance of immune
system–neuronal interactions in the modulation of brain function, one example of which is …

Pathophysiology of peripheral neuropathic pain: immune cells and molecules

MA Thacker, AK Clark, F Marchand… - Anesthesia & …, 2007 - journals.lww.com
Damage to the peripheral nervous system often leads to chronic neuropathic pain characterized
by spontaneous pain and an exaggerated response to painful and/or innocuous stimuli. …

CCL2 is a key mediator of microglia activation in neuropathic pain states

…, PK Yip, LDF Moon, SWN Thompson, F Marchand… - European journal of …, 2009 - Elsevier
While neuroimmune interactions are increasingly recognized as important in nociceptive
processing, the nature and functional significance of these interactions is not well defined. …

P2X7-dependent release of interleukin-1β and nociception in the spinal cord following lipopolysaccharide

AK Clark, AA Staniland, F Marchand… - Journal of …, 2010 - Soc Neuroscience
The cytokine interleukin-1β (IL-1β) released by spinal microglia in enhanced response states
contributes significantly to neuronal mechanisms of chronic pain. Here we examine the …

Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions

S Pezet, F Marchand, R D'Mello, J Grist… - Journal of …, 2008 - Soc Neuroscience
Here, we show that phosphatidylinositol 3-kinase (PI3K) is a key player in the establishment
of central sensitization, the spinal cord phenomenon associated with persistent afferent …

Effects of Etanercept and Minocycline in a rat model of spinal cord injury

F Marchand, C Tsantoulas, D Singh, J Grist… - European Journal of …, 2009 - Elsevier
Loss of function is usually considered the major consequence of spinal cord injury (SCI).
However, pain severely compromises the quality of life in nearly 70% of SCI patients. The …

Gabapentin reverses microglial activation in the spinal cord of streptozotocin-induced diabetic rats

R Wodarski, AK Clark, J Grist, F Marchand… - European journal of …, 2009 - Elsevier
Diabetes mellitus is the leading cause of peripheral neuropathy worldwide. Despite this
high level of incidence, underlying mechanisms of the development and maintenance of …

Animal models of chemotherapy-evoked painful peripheral neuropathies

N Authier, D Balayssac, F Marchand, B Ling… - …, 2009 - Springer
This review examines recent preclinical research on toxic peripheral neuropathy and potential
therapeutic developments. Chemotherapy-induced peripheral neurotoxicity is a major …