Biodistribution and radiation dosimetry of the amyloid imaging agent 11C-PIB in humans

…, TK Tolvanen, IA Wilson, EM Arponen… - Journal of Nuclear …, 2007 - Soc Nuclear Med
We investigated the biodistribution and radiation dosimetry of the PET amyloid imaging agent
11 C-PIB ( 11 C-6-OH-BTA-1) (where BTA is benzothiazole) in humans. Previous radiation …

Social touch modulates endogenous μ-opioid system activity in humans

…, R Dunbar, J Hirvonen, S Manninen, E Arponen… - NeuroImage, 2016 - Elsevier
In non-human primates, opioid-receptor blockade increases social grooming, and the
endogenous opioid system has therefore been hypothesized to support maintenance of long-term …

Mesolimbic dopamine release is linked to symptom severity in pathological gambling

…, A Ollikainen, MM Hirvonen, P Piepponen, E Arponen… - Neuroimage, 2012 - Elsevier
BACKGROUND: Brain dopamine neurons code rewarding environmental stimuli by releasing
endogenous dopamine, a transmission signal that is important for reinforcement learning. …

Functional imaging of localized prostate cancer aggressiveness using 11C-acetate PET/CT and 1H-MR spectroscopy

…, K Dean, K Alanen, E Arponen, M Nurmi… - Journal of Nuclear …, 2010 - Soc Nuclear Med
We assessed the ability of 11 C-acetate PET/CT, MRI, and proton MR spectroscopy ( 1 H-MRS)
to image localized prostate cancer and detect its aggressiveness, using qualitative and …

Social laughter triggers endogenous opioid release in humans

…, T Karjalainen, J Hirvonen, E Arponen… - Journal of …, 2017 - Soc Neuroscience
The size of human social networks significantly exceeds the network that can be maintained
by social grooming or touching in other primates. It has been proposed that endogenous …

Improved detection of localized prostate cancer using co-registered MRI and 11C-acetate PET/CT

…, K Dean, K Alanen, E Arponen, M Nurmi… - European journal of …, 2012 - Elsevier
OBJECTIVES: We aimed to study the ability of contrast enhanced MRI at 1.5T and 11 C-acetate
PET/CT, both individually and using fused data, to detect localized prostate cancer. …

Assessment of islet specificity of dihydrotetrabenazine radiotracer binding in rat pancreas and human pancreas

…, KK Mikkola, T Ishizu, E Arponen… - Journal of Nuclear …, 2010 - Soc Nuclear Med
… The results were documented by taking a high-magnification composite photograph of a
stained section with a 10× objective on a Zeiss Axiovert 200 M microscope (Carl Zeiss Inc.) …

[HTML][HTML] Opioid release after high-intensity interval training in healthy human subjects

…, JJ Tuulari, L Nummenmaa, E Arponen… - …, 2018 - nature.com
Central opioidergic mechanisms may modulate the positive effects of physical exercise such
as mood elevation and stress reduction. How exercise intensity and concomitant effective …

[HTML][HTML] Dopamine and opioid neurotransmission in behavioral addictions: a comparative PET study in pathological gambling and binge eating

…, T Lahti, H Alho, J Hirvonen, E Arponen… - …, 2017 - nature.com
Although behavioral addictions share many clinical features with drug addictions, they show
strikingly large variation in their behavioral phenotypes (such as in uncontrollable gambling …

Carbon-11 acetate PET/CT based dose escalated IMRT in prostate cancer

J Seppälä, M Seppänen, E Arponen, P Lindholm… - Radiotherapy and …, 2009 - Elsevier
… Parameters used for the LKB model for bladder complications were n = 0.12, m = 0.15 and
TD 50 … [20] and those used for rectal complications were n = 0.084, m = 0.108 and TD 50 …