[PDF][PDF] 18F-labeling of peptides by means of an organosilicon-based fluoride acceptor

R Schirrmacher, G Bradtmoller… - … EDITION IN ENGLISH …, 2006 - academia.edu
Fluorine-18 is among the most commonly used radionuclides for positron emission tomography
(PET).[1] This non-invasive imaging technique is capable of providing in vivo information …

Recent developments and trends in 18F-radiochemistry: syntheses and applications

R Schirrmacher, C Wangler… - Mini-Reviews in …, 2007 - ingentaconnect.com
In this short review we describe recent methods and novel trends for the introduction of
fluorine-18 into molecules which in turn are intended to serve as imaging agents for the in vivo …

Synthesis of p-(Di-tert-butyl[18F]fluorosilyl)benzaldehyde ([18F]SiFA-A) with High Specific Activity by Isotopic Exchange: A Convenient Labeling Synthon for the 18 …

E Schirrmacher, B Wängler, M Cypryk… - Bioconjugate …, 2007 - ACS Publications
The syntheses of different 18 F-labeled peptides using the highly effective labeling synthon
p-(di-tert-butylfluorosilyl) benzaldehyde ([ 18 F]SiFA-A) for the development of 18 F-…

One-step 18F-labeling of peptides for positron emission tomography imaging using the SiFA methodology

…, J Chin, K Orchowski, E Schirrmacher… - nature protocols, 2012 - nature.com
Here we present a procedure to label peptides with the positron-emitting radioisotope
fluorine-18 (18 F) using the silicon-fluoride acceptor (SiFA) labeling methodology. Positron …

para‐Functionalized Aryl‐di‐tert‐butylfluorosilanes as Potential Labeling Synthons for 18F Radiopharmaceuticals

…, E Schirrmacher, R Schirrmacher… - … A European Journal, 2009 - Wiley Online Library
Broad spectrum: Novel para‐functionalized aryl‐di‐tert‐butylfluorosilanes, p‐(tBu 2 FSi)C 6
H 4 X (X=functional group), have been made available and broaden the spectrum of silicon‐…

Small prosthetic groups in 18F-radiochemistry: useful auxiliaries for the design of 18F-PET tracers

R Schirrmacher, B Wängler, J Bailey… - Seminars in nuclear …, 2017 - Elsevier
Prosthetic group (PG) applications in 18 F-radiochemistry play a pivotal role among current
18 F - labeling techniques for the development and availability of 18 F-labeled imaging …

Kit-Like 18F-Labeling of Proteins: Synthesis of 4-(Di-tert-butyl[18F]fluorosilyl)benzenethiol (Si[18F]FA-SH) Labeled Rat Serum Albumin for Blood Pool Imaging with …

…, G Quandt, L Iovkova, E Schirrmacher… - Bioconjugate …, 2009 - ACS Publications
Radiosyntheses of 18 F-radiopharmaceuticals for positron emission tomography (PET)
normally require an extraordinarily high effort of technical equipment and specially trained …

[HTML][HTML] 18F-Labeled Silicon-Based Fluoride Acceptors: Potential Opportunities for Novel Positron Emitting Radiopharmaceuticals

…, C Wängler, E Schirrmacher… - BioMed research …, 2014 - hindawi.com
Background. Over the recent years, radiopharmaceutical chemistry has experienced a wide
variety of innovative pushes towards finding both novel and unconventional radiochemical …

Human concentrative nucleoside transporter 1-mediated uptake of 5-azacytidine enhances DNA demethylation

…, D Keller, M Brom, E Schirrmacher… - Molecular cancer …, 2009 - AACR
The DNA methyltransferase inhibitors 5-azacytidine (5-azaCyd) and 5-aza-2′-deoxycytidine
have found increasing use for the treatment of myeloid leukemias and solid tumors. Both …

Imaging in Vivo Glutamate Fluctuations with [11C]ABP688: A GLT-1 Challenge with Ceftriaxone

…, A Aliaga, L Moquin, ES Schirrmacher… - Journal of Cerebral …, 2015 - journals.sagepub.com
Molecular imaging offers unprecedented opportunities for investigating dynamic changes
underlying neuropsychiatric conditions. Here, we evaluated whether [ 11 C]ABP688, a positron …