Neuroblastoma is a malignant paediatric tumour of the sympathetic nervous system 1 . Roughly
half of these tumours regress spontaneously or are cured by limited therapy. By contrast, …

Real-time detection of the rates of metabolic flux, or exchange rates of endogenous enzymatic
reactions, is now feasible in biological systems using Dynamic Nuclear Polarization …

Objective Microsatellite instability (MSI) is detected in approximately 15% of all colorectal
cancers (CRC) and virtually in all cases with Lynch syndrome. The MSI phenotype is caused …

Introduction Detection of somatic genomic alterations in the plasma of patients with cancer (“liquid
biopsy”) are increasingly being used in the clinic. However, the concordance of …

Myocardial hypoxia is an attractive target for diagnostic and prognostic imaging, but current
approaches are insufficiently sensitive for clinical use. The PET tracer copper(II)-diacetyl-bis(…

The subtle hypoxia underlying chronic cardiovascular disease is an attractive target for PET
imaging, but the lead hypoxia imaging agents 64 Cu-2,3-butanedione bis(N4-…

Hyperpolarized 13 C MR measurements have the potential to display non‐linear kinetics.
We have developed an approach to describe possible non‐first‐order kinetics of …

Background The trapping mechanisms of the PET hypoxia imaging agent copper(II)-diacetyl-bis(N
4 -methylthiosemicarbazone) ( 64 Cu(ATSM)) remain unresolved, although its …

Background The present prospective study aimed at determining the impact of cell-free tumor
DNA (ct-DNA), CA125 and HE4 from blood and ascites for quantification of tumor burden …

Background The Langendorff perfused heart is a physiologically relevant and controllable
model with potential for assessing the pharmacokinetics of new radiotracers under a range of …