Context.— In 2013, an evidence-based guideline was published by the College of
American Pathologists, the International Association for the Study of Lung Cancer, and the …

Introduction: Adenocarcinoma is the most common histologic type of lung cancer. To
address advances in oncology, molecular biology, pathology, radiology, and surgery of lung …

Background There are limited data from randomized trials regarding whether volume-based,
low-dose computed tomographic (CT) screening can reduce lung-cancer mortality among …

We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest
human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 …

Objective To establish evidence-based recommendations for the molecular analysis of lung
cancers that are that are required to guide EGFR- and ALK-directed therapies, addressing …

Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis 1 ,
2 , 3 . We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an …

Lung cancer remains one of the leading causes of cancer-related death in developed countries.
Although lung adenocarcinomas with EGFR mutations or EML4-ALK fusions respond to …

Background The use of multidetector computed tomography (CT) in lung-cancer screening
trials involving subjects with an increased risk of lung cancer has highlighted the problem for …

… Thunnissen reports personal fees from HistoGeneX and Ventana Roche during the conduct
of the study. Dr. Wistuba reports grants and personal fees from Genentech/Roche, Bristol-…

The new International Association for the Study of Lung Cancer/American Thoracic Society/European
Respiratory Society lung adenocarcinoma classification provides, for the first time, …