Myofibroblasts, and the extracellular matrix ( ECM ) in which they reside, are critical components
of wound healing and fibrosis. The ECM , traditionally viewed as the structural elements …

Respiratory disease is the third leading cause of death in the industrialized world. Consequently,
the trachea, lungs, and cardiopulmonary vasculature have been the focus of extensive …

Tissue injury evokes highly conserved, tightly regulated inflammatory responses and less
well-understood host repair responses. Both inflammation and repair involve the recruitment, …

10.7554/eLife.05098.001 Recent breakthroughs in 3-dimensional (3D) organoid cultures for
many organ systems have led to new physiologically complex in vitro models to study …

Myofibroblast differentiation and activation by transforming growth factor-ॆ1 (TGF-ॆ1) is a
critical event in the pathogenesis of human fibrotic diseases, but regulatory mechanisms for …

Rationale: Extracellular matrix (ECM) is a dynamic tissue that contributes to organ integrity
and function, and its regulation of cell phenotype is a major aspect of cell biology. However, …

Pathological remodeling of the extracellular matrix (ECM) by fibroblasts leads to organ
failure. Development of idiopathic pulmonary fibrosis (IPF) is characterized by a progressive …

In the second edition of the definitive account of Igor Stravinsky's life and work, arranged in
two separate sections, Eric Walter White revised the whole book, completing the biographical …

Rationale: Ineffective repair of a damaged alveolar epithelium has been postulated to cause
pulmonary fibrosis. In support of this theory, epithelial cell abnormalities, including …

The pulmonary extracellular matrix (ECM) determines the tissue architecture of the lung, and
provides mechanical stability and elastic recoil, which are essential for physiological lung …