Our understanding of Alzheimer’s disease (AD) pathophysiology remains incomplete. Here
we used quantitative mass spectrometry and coexpression network analysis to conduct the …

The pathophysiological process of Alzheimer’s disease (AD) is thought to begin many years
before the diagnosis of AD dementia. This long “preclinical” phase of AD would provide a …

Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …

The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …

Background Variants of the apolipoprotein E allele appear to account for most cases of late-onset
Alzheimer's disease, and persons with two copies of the ε4 allele appear to have an …

Vascular contributions to dementia and Alzheimer’s disease are increasingly recognized 1 ,
2 , 3 , 4 , 5 – 6 . Recent studies have suggested that breakdown of the blood–brain barrier (…

Importance There are limitations in current diagnostic testing approaches for Alzheimer
disease (AD). Objective To examine plasma tau phosphorylated at threonine 217 (P-tau217) as …

Substantial evidence suggests that a key distinction in the classification of human emotion is
that between an appetitive motivational system associated with positive or pleasant emotion …

Context The ability to identify and quantify brain β-amyloid could increase the accuracy of a
clinical diagnosis of Alzheimer disease. Objective To determine if florbetapir F 18 positron …

Fluorodeoxyglucose positron emission tomography (PET) studies have found that patients
with Alzheimer's dementia (AD) have abnormally low rates of cerebral glucose metabolism in …