We sought to develop 11 C-labeled ligands for sensitive imaging of brain peripheral
benzodiazepine receptors (PBR) in vivo. Two aryloxyanilides with high affinity for PBR were …

Bicycloalkyl groups have been previously described as phenyl group bioisosteres. This
article describes the synthesis of new building blocks allowing their introduction into complex …

Peripheral benzodiazepine receptors (PBRs) are upregulated on activated microglia. We
recently developed a promising positron emission tomography (PET) ligand, [ 11 C]PBR28, …

OBJECTIVES: Peripheral benzodiazepine receptors (PBRs) are upregulated on activated
microglia and are thereby biomarkers of neuroinflammation. We developed a PET ligand with …

Carboxylic esters were successfully labeled with one of two short-lived positron-emitters,
carbon-11 or fluorine-18, within a hydrodynamically-driven micro-reactor. The non-radioactive …

This study evaluated 18 F-labeled IMPY [6-iodo-2-(4‘-N,N-dimethylamino)phenylimidazo[1,2-a]pyridine]
derivatives as agents for imaging β-amyloid plaque with positron emission …

Elevated levels of peripheral benzodiazepine receptors (PBR) are associated with activated
microglia in their response to inflammation. Hence, PBR imaging in vivo is valuable for …

Peripheral benzodiazepine receptors (PBRs) are upregulated on activated microglia and
are, thereby, biomarkers of cellular inflammation in brain. We recently developed two PET …

Background Siponimod (BAF312), a selective S1P 1 /S1P 5 agonist, reduces disability
progression in secondary progressive MS. Recent observations suggest it could act via S1P 1 /…

Motivation can critically influence learning and memory. Multiple neural mechanisms regulate
motivational states, among which signalling via specific neuropeptides, such as NPY in …