Circadian biology modulates almost all aspects of mammalian physiology, disease, and
response to therapies. Emerging data suggest that circadian biology may significantly affect the …

Measurements of oxygen partial pressure (pO 2 ) with high temporal and spatial resolution
in three dimensions is crucial for understanding oxygen delivery and consumption in normal …

Multiparametric magnetic resonance imaging (MRI) has become a critical clinical tool for
diagnosing focal ischemic stroke severity, staging treatment, and predicting outcome. Imaging …

The blood oxygenation level-dependent (BOLD) contrast is widely used in functional magnetic
resonance imaging (fMRI) studies aimed at investigating neuronal activity. However, the …

What is the organization of cerebral microvascular oxygenation and morphology that allows
adequate tissue oxygenation at different activity levels? We address this question in the …

Blood–brain barrier (BBB) dysfunction, eg, increase in BBB permeability, has been reported
to contribute to cognitive impairment. However, the effects of anesthesia and surgery on …

Circadian and diurnal variation in cerebral blood flow directly contributes to the diurnal
variation in the risk of stroke, either through factors that trigger stroke or due to impaired …

Background and Purpose— White matter injury caused by cerebral hypoperfusion may
contribute to the pathophysiology of vascular dementia and stroke, but the underlying …

To date, two main categories of OCT techniques have been described for imaging
hemodynamics: Doppler OCT and OCT angiography. Doppler OCT can measure axial velocity …

At low levels, carbon monoxide (CO) has physiological roles as a second messenger and
neuromodulator 1, 2. Here we assess the effects of CO in a mouse model of traumatic brain …