NanoLuc: a small luciferase is brightening up the field of bioluminescence

CG England, EB Ehlerding, W Cai - Bioconjugate chemistry, 2016 - ACS Publications
The biomedical field has greatly benefited from the discovery of bioluminescent proteins.
Currently, scientists employ bioluminescent systems for numerous biomedical applications, …

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

D Ni, W Bu, EB Ehlerding, W Cai, J Shi - Chemical Society Reviews, 2017 - pubs.rsc.org
Magnetic resonance imaging (MRI) is a highly valuable non-invasive imaging tool owing to
its exquisite soft tissue contrast, high spatial resolution, lack of ionizing radiation, and wide …

Theranostic nanoparticles

F Chen, EB Ehlerding, W Cai - Journal of nuclear medicine, 2014 - Soc Nuclear Med
Theranostic nanoparticles hold the potential to revolutionize disease management. Over the
last decade, there has been growing interest in the engineering of various kinds of …

Biodegradable and renal clearable inorganic nanoparticles

EB Ehlerding, F Chen, W Cai - Advanced Science, 2016 - Wiley Online Library
Personalized treatment plans for cancer therapy have been at the forefront of oncology
research for many years. With the advent of many novel nanoplatforms, this goal is closer to …

Preclinical pharmacokinetics and biodistribution studies of 89Zr-labeled pembrolizumab

CG England, EB Ehlerding, R Hernandez… - Journal of Nuclear …, 2017 - Soc Nuclear Med
Pembrolizumab is a humanized monoclonal antibody targeting programmed cell death protein
1 (PD-1) found on T and pro-B cells. Pembrolizumab prevents PD-1 ligation by both PD-…

In Vivo Tumor Vasculature Targeting of CuS@MSN Based Theranostic Nanomedicine

…, H Hong, S Goel, SA Graves, H Orbay, EB Ehlerding… - ACS …, 2015 - ACS Publications
Actively targeted theranostic nanomedicine may be the key for future personalized cancer
management. Although numerous types of theranostic nanoparticles have been developed in …

Bioresponsive polyoxometalate cluster for redox-activated photoacoustic imaging-guided photothermal cancer therapy

D Ni, D Jiang, HF Valdovinos, EB Ehlerding, B Yu… - Nano …, 2017 - ACS Publications
Although various types of imaging agents have been developed for photoacoustic (PA)
imaging, relatively few imaging agents exhibit high selectivity/sensitivity to the tumor …

Surface engineering of graphene-based nanomaterials for biomedical applications

S Shi, F Chen, EB Ehlerding, W Cai - Bioconjugate chemistry, 2014 - ACS Publications
Graphene-based nanomaterials have attracted tremendous interest over the past decade
due to their unique electronic, optical, mechanical, and chemical properties. However, the …

A melanin‐based natural antioxidant defense nanosystem for theranostic application in acute kidney injury

…, D Jiang, ZT Rosenkrans, EB Ehlerding… - Advanced functional …, 2019 - Wiley Online Library
Acute kidney injury (AKI) is frequently associated with oxidative stress and causes high
mortality annually in clinics. Nanotechnology‐mediated antioxidative therapy is emerging as a …

Big potential from small agents: nanoparticles for imaging-based companion diagnostics

EB Ehlerding, P Grodzinski, W Cai, CH Liu - ACS nano, 2018 - ACS Publications
The importance of medical imaging in the diagnosis and monitoring of cancer cannot be
overstated. As personalized cancer treatments are gaining popularity, a need for more …