Superiority of yeast over bacterial cytosine deaminase for enzyme/prodrug gene therapy in colon cancer xenografts
E Kievit, E Bershad, E Ng, P Sethna, I Dev… - Cancer research, 1999 - AACR
The enzyme/prodrug strategy using bacterial cytosine deaminase (bCD) and 5-fluorocytosine
(5-FC) is currently under investigation for cancer gene therapy. A major limitation for the …
(5-FC) is currently under investigation for cancer gene therapy. A major limitation for the …
[PDF][PDF] Zirconium-labeled monoclonal antibodies and their distribution in tumor-bearing nude mice
…, RP Klok, FB Van Gog, E Kievit… - Journal of Nuclear …, 1997 - Soc Nuclear Med
Methods: The bifunctionalchelating agent desterai (Df) was linked through a thioether bond
to the MAbs. Labeling was accomplished by addition of the premodified antibodies to …
to the MAbs. Labeling was accomplished by addition of the premodified antibodies to …
Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy
…, A Rehemtulla, B Beattie, E Kievit… - Proceedings of the …, 1999 - National Acad Sciences
Analysis of transgene expression in vivo currently requires destructive and invasive
molecular assays of tissue specimens. Noninvasive methodology for assessing the location, …
molecular assays of tissue specimens. Noninvasive methodology for assessing the location, …
Yeast cytosine deaminase improves radiosensitization and bystander effect by 5-fluorocytosine of human colorectal cancer xenografts
E Kievit, MK Nyati, E Ng, LD Stegman, J Parsels… - Cancer research, 2000 - AACR
The efficacy of cancer gene therapy using bacterial cytosine deaminase(bCD)/5-fluorocytosine
(5-FC) enzyme/prodrug strategy is limited by the inefficiency of cytosine deaminase (CD)-…
(5-FC) enzyme/prodrug strategy is limited by the inefficiency of cytosine deaminase (CD)-…
Comparison of the biodistribution and the efficacy of monoclonal antibody 323/A3 labeled with either 131I or 186Re in human ovarian cancer xenografts.
E Kievit, FB Van Gog, HM Schlüper… - … journal of radiation …, 1997 - europepmc.org
Purpose The radionuclide 186Re has favorable physical characteristics for use in
radioimmunotherapy, including the emission of beta-particles of a high-energy and a low-abundance …
radioimmunotherapy, including the emission of beta-particles of a high-energy and a low-abundance …
Addition of cisplatin improves efficacy of 131I-labeled monoclonal antibody 323A3 in experimental human ovarian cancer
E Kievit, HM Pinedo, HMM Schlüper, E Boven - International Journal of …, 1997 - Elsevier
Purpose : This study was conducted to determine whether the cytotoxic agent cisplatin (CDDP),
also known as a radiosensitizer, can improve the efficacy of the 131 I-labeled …
also known as a radiosensitizer, can improve the efficacy of the 131 I-labeled …
Extracellular expression of cytosine deaminase results in increased 5-FU production for enhanced enzyme/prodrug therapy
A Rehemtulla, DA Hamstra, E Kievit… - Anticancer …, 2004 - ar.iiarjournals.org
Background: The cytosine deaminase/5-fluorocytosine (CD/5-FC), strategy for cancer gene
therapy shows considerable promise in experimental models but, because CD is a cytosolic …
therapy shows considerable promise in experimental models but, because CD is a cytosolic …
Determination of tumor‐related factors of influence on the uptake of the monoclonal antibody 323/A3 in experimental human ovarian cancer
E Kievit, HM Pinedo, HMM Schlüper… - … journal of cancer, 1997 - Wiley Online Library
The epithelial glycoprotein 40 (EGP40) is an important target in the clinic for radioimmunolocalization
and monoclonal antibody (MAb)‐mediated therapy of cancer. We determined …
and monoclonal antibody (MAb)‐mediated therapy of cancer. We determined …
[186Re]-labeled mouse and chimeric monoclonal antibody 323/A3: A comparison of the efficacy in experimental human ovarian cancer
E Kievit, FB Van Gog, HMM Schlüper… - Nuclear medicine and …, 1998 - Elsevier
We have investigated whether [ 186 Re]-labeled chimeric monoclonal antibody 323/A3 (MAb
C-323/A3) is as effective as [ 186 Re]-labeled mouse 323/A3 (m-323/A3) in the growth …
C-323/A3) is as effective as [ 186 Re]-labeled mouse 323/A3 (m-323/A3) in the growth …
[HTML][HTML] Friendships and family support reduce subsequent depressive symptoms in at-risk adolescents
… Our findings suggest a cascading effect of ELS on later life. We find support that CFA is …
Crucially, despite these cascading negative effects of ELS on later interactions, our findings also …
Crucially, despite these cascading negative effects of ELS on later interactions, our findings also …