A33, a monoclonal antibody that targets colon carcinomas, was labeled with 125 I or 131 I
and the relative therapeutic efficacy of the 2 radiolabeled species was compared in a human …

External Beam Radiotherapy: Comparative Page 1 range of tumor models, antibodies,
radiolabels and irradia tion procedures, making direct comparisons difficult. RIT was more …

Label retention assays remain the state‐of‐the‐art approach to identify the location of intraorgan
epithelial stem cell niches, in situ and in vivo. They are commonly used in organs with …

A novel α-particle emitting monoclonal antibody construct targeting the external domain of
prostate-specific membrane antigen (PSMA) was prepared and evaluated in vitro and in vivo. …

Inradioimmunotherapy, the emission characteristics of the radioisotope is critical in determining
the radiation dose to the tumor compared to normal organs. If antibodies internalize and …

Monoclonal antibody (mAb) A33 reacts with an antigen expressed by > 95% of colon cancer
and normal colon epithelial cells. An earlier Phase I trial of 131 I-labeled mAb A33 ( 131 I-…

… Cells were cultured at 37C in an incubator containing 5% C02 and harvested using 0.1% …
antibody (791T/36) and its Fab/c fragment in mice with tumour xenografts revealed by the use …

… IUT AND XRT XENOGRAFT RESPONSE •Barendswaard … Humm Els C. Barendswaard,
Joseph A. O'Donoghue, Steven M. Larson, Jörg Tschmelitsch, Sydney Welt, Ronald D. …

… ) or 99m Tc-R3B23 (e–g) in naive (a, e), 5T33MM (b, f) or 5T2MM mice (c, g). One … (c)
Weight of spleen after 7 weeks of treatment with 177 Lu-R3B23. *P<0.05; **P<0.005; ***P…

… These controls maintained high levels of hyperglycemia for the duration of the experiments
and some of them died at around 100 days. By contrast, the glucose levels in STZ-treated …