Metformin is one of the most popular oral glucose-lowering medications, widely considered
to be the optimal initial therapy for patients with type 2 diabetes mellitus. Interestingly, there …

In rodent models, obesity and hyperglycemia alter cerebral glucose metabolism and glucose
transport into the brain, resulting in disordered cerebral function as well as inappropriate …

Glucose is the primary energy source for the brain, and exposure to both high and low
levels of glucose has been associated with numerous adverse central nervous system (CNS) …

In the century since the discovery of insulin, diabetes has changed from an early death
sentence to a manageable chronic disease. This change in longevity and duration of diabetes …

The impact of glycemic variability on brain glucose transport kinetics among individuals with
type 1 diabetes mellitus (T1DM) remains unclear. Fourteen individuals with T1DM (age 35 ± …

Type 1 diabetes mellitus (T1DM) has traditionally been characterized by a complete
destruction of β-cell mass (BCM); however, there is growing evidence of possible residual BCM …

The energy-dissipating properties of brown adipose tissue (BAT) have been proposed as
therapeutic targets for obesity and diabetes. Little is known about basal BAT activity. …

Aims/hypothesis We have previously shown that individuals with uncontrolled type 2
diabetes have a blunted rise in brain glucose levels measured by 1 H magnetic resonance …

Purpose Changes in blood glucose levels have been shown to influence eating in healthy
individuals; however, less is known about effects of glucose on food intake in individuals who …

Context Most heritable causes of low bone mass in children occur due to mutations affecting
type 1 collagen. We describe two related patients with low bone mass and fracture without …