Despite epidemiological and genetic data linking semantic dementia to inflammation, the
topography of neuroinflammation in semantic dementia, also known as the semantic variant of …

Neuroimaging in the preclinical phase of Alzheimer’s disease provides information crucial
to early intervention, particularly in people with a high genetic risk. Metabolic network …

Although abnormally folded tau protein has been found to self-propagate from neuron to
connected neuron, similar propagation through human brain networks has not been fully …

Objective: Recently, a M4 muscarinic cholinergic receptor PET tracer has been developed
that shows good imaging characteristics. We report on the first group of AD patients to be …

Amyloid-negative pathology underlying primary progressive prosopagnosia usually affects
the tip of the right temporal lobe first. However, a 69-year-old right-handed man, with amyloid-…

Objective: To identify tau deposition in the sporadic nonfluent/agrammatic variant of primary
progressive aphasia (nfvPPA) using 18 F-AV-1451 PET. Background: nfvPPA is …

Objective: We studied whether there was an association between flortaucipir ([ 18 F]AV-1451)
uptake and neuroinflammation, measured with the TSPO tracer 11 C-PBR28. Background: …

101 Introduction: Semantic variant primary progressive aphasia (svPPA) has a characteristic
clinical phenotype defined by cognitive and imaging findings. Anomia and single word …

Dynamic contrast-enhanced MRI (DCE-MRI) acquires T 1 -weighted MRI scans before and
after injection of an MRI contrast agent such as gadolinium (Gd). Gadolinium causes the …

Background Neuroinflammation, a hallmark of frontotemporal dementia, has been sparsely
studied in vivo. However, neuroinflammation is a potentially important therapeutic target and …