User profiles for Eftychia Koumarianou
 | Eftychia KoumarianouSenior Research Fellow, LTMI/CSCB, Duke-NUS Medical School Verified email at duke-nus.edu.sg Cited by 862 |
(2S)-2-(3-(1-carboxy-5-(4-211At-astatobenzamido) pentyl) ureido)-pentanedioic acid for PSMA-targeted α-particle radiopharmaceutical therapy
…, Y Chen, J Choi, E Koumarianou… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Alpha-particle emitters have a high linear energy transfer and short range, offering the
potential for treating micrometastases while sparing normal tissues. We developed a urea-based, …
potential for treating micrometastases while sparing normal tissues. We developed a urea-based, …
Targeting breast carcinoma with radioiodinated anti-HER2 Nanobody
INTRODUCTION: With a molecular weight an order of magnitude lower than antibodies but
possessing comparable affinities, Nanobodies (Nbs) are attractive as targeting agents for …
possessing comparable affinities, Nanobodies (Nbs) are attractive as targeting agents for …
Improved tumor targeting of anti-HER2 nanobody through N-succinimidyl 4-guanidinomethyl-3-iodobenzoate radiolabeling
M Pruszynski, E Koumarianou… - Journal of nuclear …, 2014 - Soc Nuclear Med
Nanobodies are approximately 15-kDa proteins based on the smallest functional fragments
of naturally occurring heavy chain–only antibodies and represent an attractive platform for …
of naturally occurring heavy chain–only antibodies and represent an attractive platform for …
Preclinical evaluation of 18F-labeled anti-HER2 nanobody conjugates for imaging HER2 receptor expression by immuno-PET
…, D McDougald, J Choi, E Koumarianou… - Journal of Nuclear …, 2016 - Soc Nuclear Med
The human growth factor receptor type 2 (HER2) is overexpressed in breast as well as other
types of cancer. Immuno-PET, a noninvasive imaging procedure that could assess HER2 …
types of cancer. Immuno-PET, a noninvasive imaging procedure that could assess HER2 …
Astatine-211 labeled anti-HER2 5F7 single domain antibody fragment conjugates: radiolabeling and preliminary evaluation
J Choi, G Vaidyanathan, E Koumarianou… - Nuclear medicine and …, 2018 - Elsevier
Introduction Derived from heavy chain only camelid antibodies, ~ 15-kDa single-domain
antibody fragments (sdAbs) are an attractive platform for developing molecularly specific …
antibody fragments (sdAbs) are an attractive platform for developing molecularly specific …
Radiolabeling and in vitro evaluation of 67Ga-NOTA-modular nanotransporter–A potential Auger electron emitting EGFR-targeted radiotherapeutic
Introduction Modular nanotransporters (MNTs) are vehicles designed to transport drugs
from the cell surface via receptor-mediated endocytosis and endosomal escape to nucleus. …
from the cell surface via receptor-mediated endocytosis and endosomal escape to nucleus. …
[HTML][HTML] Modular nanotransporters: a versatile approach for enhancing nuclear delivery and cytotoxicity of Auger electron-emitting 125I
Background This study evaluates the potential utility of a modular nanotransporter (MNT) for
enhancing the nuclear delivery and cytotoxicity of the Auger electron emitter 125 I in cancer …
enhancing the nuclear delivery and cytotoxicity of the Auger electron emitter 125 I in cancer …
Comparative study on DOTA-derivatized bombesin analog labeled with 90Y and 177Lu: in vitro and in vivo evaluation
E Koumarianou, R Mikołajczak, D Pawlak… - Nuclear medicine and …, 2009 - Elsevier
INTRODUCTION: The aim of the study was to compare in vitro and in vivo a novel DOTA-chelated
bombesin (BN) analog of the amino acid sequence, QRLGNQWAVGHLM-CONH 2 (BN…
bombesin (BN) analog of the amino acid sequence, QRLGNQWAVGHLM-CONH 2 (BN…
Comparison of receptor affinity of nat Sc-DOTA-TATE versus nat Ga-DOTA-TATE
E Koumarianou, D Pawlak, A Korsak… - Nuclear Medicine …, 2011 - journals.viamedica.pl
BACKGROUND: 44 Sc as a positron emitter can be an interesting alternative to 68 Ga (T ½=
67.71 min) due to its longer half-life (T ½= 3.97 h). Moreover, the b–emitter 47 Sc can be …
67.71 min) due to its longer half-life (T ½= 3.97 h). Moreover, the b–emitter 47 Sc can be …
N-Succinimidyl 3-((4-(4-[18 F] fluorobutyl)-1 H-1, 2, 3-triazol-1-yl) methyl)-5-(guanidinomethyl) benzoate ([18 F] SFBTMGMB): a residualizing label for 18 F-labeling of …
…, J Choi, M Pruszynski, E Koumarianou… - Organic & …, 2016 - pubs.rsc.org
Residualizing labeling methods for internalizing peptides and proteins are designed to trap
the radionuclide inside the cell after intracellular degradation of the biomolecule. The goal of …
the radionuclide inside the cell after intracellular degradation of the biomolecule. The goal of …