Tumor molecular profiling is a fundamental component of precision oncology, enabling the
identification of genomic alterations in genes and pathways that can be targeted …

A main limitation of therapies that selectively target kinase signalling pathways is the
emergence of secondary drug resistance. Cetuximab, a monoclonal antibody that binds the …

Metastatic colorectal cancers (mCRCs) are clinically heterogeneous, but the genomic basis
of this variability remains poorly understood. We performed prospective targeted sequencing …

Poorly differentiated neuroendocrine carcinomas (NECs) of the pancreas are rare
malignant neoplasms with a poor prognosis. The aim of this study was to determine the …

Importance Treatment of locally advanced rectal (LARC) cancer involves chemoradiation,
surgery, and chemotherapy. The concept of total neoadjuvant therapy (TNT), in which …

The efficacy of KRAS G12C inhibitors in NSCLC and colorectal cancer is lineage-specific.
RTK dependency and signaling rebound kinetics are responsible for sensitivity or resistance …

Importance The watch-and-wait (WW) strategy aims to spare patients with rectal cancer
unnecessary resection. Objective To analyze the outcomes of WW among patients with rectal …

Aberrant Wnt signaling can drive cancer development. In many cancer types, the genetic
basis of Wnt pathway activation remains incompletely understood. Here, we report recurrent …

Background Colorectal cancer is the second leading cause of cancer death in the United
States, with over 50,000 deaths estimated in 2014. Molecular profiling for somatic mutations …

The incidence of esophagogastric cancer is rapidly rising, but only a minority of patients
derive durable benefit from current therapies. Chemotherapy as well as anti-HER2 and PD-1 …