Neutrophils play a key role in the elimination of pathogens. They are remarkably short-lived
with a circulating half life of 6–8h and hence are produced at a rate of 5×10 10 –10×10 10 …

… Cowburn, Nicola Johnson, Edwin R. Chilvers; Hypoxia-induced neutrophil survival is mediated
by HIF-1α–dependent NF-κB activity . J Exp Med 3 January 2005; 201 (1): 105–115. doi: …

Resistance to chemotherapy is a principal problem in the treatment of small cell lung cancer
(SCLC). We show here that SCLC is surrounded by an extensive stroma of extracellular …

Genetic mutations cause primary immunodeficiencies (PIDs) that predispose to infections.
Here, we describe activated PI3K-δ syndrome (APDS), a PID associated with a dominant gain-…

The production of reactive oxygen species (ROS) by neutrophils has a vital role in defence
against a range of infectious agents, and is driven by the assembly of a multi-protein complex …

During beneficial inflammation, potentially tissue-damaging granulocytes undergo apoptosis
before being cleared by phagocytes in a non-phlogistic manner. Here we show that the rate …

It is well established that preexposure of human neutrophils to proinflammatory cytokines
markedly augments the production of reactive oxygen species (ROS) to subsequent stimuli. …

Granulocyte apoptosis is an important mechanism underlying the removal of redundant
neutrophils from an inflammatory focus. The ability of many proinflammatory agents to impede …

Neutrophils are recognized as an essential part of the innate immune response, but an active
debate still exists regarding the life cycle of these cells. Neutrophils first differentiate in the …

Copy number (CN) variation (CNV) has been shown to be common in regions of the genome
coding for immune-related genes, and thus impacts upon polygenic autoimmunity. Low CN …