[HTML][HTML] A comparison of the abuse liability of tramadol, NSAIDs, and hydrocodone in patients with chronic pain

EH Adams, S Breiner, TJ Cicero, A Geller… - Journal of pain and …, 2006 - Elsevier
Concern about abuse/dependence in chronic pain patients taking opioid analgesics may lead
to undertreatment of pain, yet little is known about the prevalence of abuse/dependence in …

A postmarketing surveillance program to monitor Ultram®(tramadol hydrochloride) abuse in the United States

TJ Cicero, EH Adams, A Geller, JA Inciardi… - Drug and alcohol …, 1999 - Elsevier
Tramadol HCl, marketed as Ultram® in the USA, was introduced as a non-scheduled drug
in April 1995 based on the assumption that the risk of abuse was sufficiently low to warrant a …

Classification and definition of misuse, abuse, and related events in clinical trials: ACTTION systematic review and recommendations

SM Smith, RC Dart, NP Katz, F Paillard, EH Adams… - Pain®, 2013 - Elsevier
As the nontherapeutic use of prescription medications escalates, serious associated
consequences have also increased. This makes it essential to estimate misuse, abuse, and related …

Challenges in the development of prescription opioid abuse-deterrent formulations

NP Katz, EH Adams, H Chilcoat… - The Clinical journal …, 2007 - journals.lww.com
Opioid analgesics remain the cornerstone of effective management for moderate-to-severe
pain. In the face of persistent lack of access to opioids by patients with legitimate pain …

Physical dependence on Ultram®(tramadol hydrochloride): Both opioid-like and atypical withdrawal symptoms occur

EC Senay, EH Adams, A Geller, JA Inciardi… - Drug and alcohol …, 2003 - Elsevier
In 1994, the Drug Abuse Advisory Committee (DAAC) of the Food and Drug Administration (FDA)
concluded that Ultram ® (tramadol hydrochloride) could be marketed as an analgesic …

The comparative burden of chronic widespread pain and fibromyalgia in the United States

…, HJ McElroy, AB Chandran, EH Adams… - Pain …, 2016 - Wiley Online Library
Background/Purpose Little information exists on the comparative patient and economic burden
of chronic widespread pain ( CWP ) and fibromyalgia ( FM ) in the United States. Methods …

Foundations of opioid risk management

NP Katz, EH Adams, JC Benneyan… - The Clinical journal …, 2007 - journals.lww.com
Increased abuse and diversion of prescription opioids has been a consequence of the
increased availability of opioids to address the widespread problem of undertreated pain. Opioid …

Rates of abuse of tramadol remain unchanged with the introduction of new branded and generic products: results of an abuse monitoring system, 1994–2004

TJ Cicero, JA Inciardi, EH Adams… - … and drug safety, 2005 - Wiley Online Library
Purpose The analgesic Tramadol HCl (Ultram™) was approved in 1994 as a non‐scheduled
drug under the CSA provided that a novel risk‐management program would be developed …

Patient satisfaction and experience with health services and quality of care

TR Zastowny, WC Stratmann, EH Adams… - Quality management in …, 1995 - journals.lww.com
This article discusses the use of patient satisfaction and personal health care experiences
as a measure of health care quality. It also presents a field-proven patient experience and …

Epidemiology of drug abuse: an overview

NJ Kozel, EH Adams - Science, 1986 - science.org
Issues regarding the use of epidemiology in drug abuse research are discussed and systems
for monitoring national trends and identifying risk factors are described. Data indicate a …