Background As compared with a standard-dose vaccine, a high-dose, trivalent, inactivated
influenza vaccine (IIV3-HD) improves antibody responses to influenza among adults 65 years …

Background We aimed to assess efficacy and safety, with a special focus on cardiovascular
safety, of the novel dual GIP and GLP-1 receptor agonist tirzepatide versus insulin glargine …

Most carbamates are pseudoirreversible inhibitors of cholinesterases. Phenothiazine
carbamates exhibit this inhibition of acetylcholinesterase but produce reversible inhibition of …

Current approaches to the treatment of cognitive and behavioral symptoms of Alzheimer
disease emphasize the use of cholinesterase inhibitors. The kinetic effects of the cholinesterase …

Histochemical analysis of Alzheimer disease (AD) brain tissues indicates that butyrylcholinesterase
(BuChE) is present in β-amyloid (Aβ) plaques. The role of BuChE in AD pathology is …

Cholinesterase inhibitors are the standard of care for Alzheimer's disease (AD). Acetylcholinesterase
(AChE) catalyzes the hydrolysis of the cholinergic neurotransmitter acetylcholine. …

Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) catalyze the hydrolysis of
the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic …

Evidence suggests that specific inhibition of butyrylcholinesterase may be an appropriate
focus for the development of more effective drugs to treat dementias such as Alzheimer’s …

Several lines of evidence indicate that inhibition of butyrylcholinesterase (BuChE) is important
in the treatment of certain dementias. Further testing of this concept requires inhibitors that …

Alzheimer’s disease (AD) is the most common neurodegenerative disorder causing dementia.
One hallmark of the AD brain is the deposition of β-amyloid (Aβ) plaques. AD is also a …