Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography

…, LA Green, E Bauer, DC MacLaren… - Proceedings of the …, 1999 - National Acad Sciences
We are developing quantitative assays to repeatedly and noninvasively image expression
of reporter genes in living animals, using positron emission tomography (PET). We …

Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice

E Kim, JD Lowenson, DC MacLaren… - Proceedings of the …, 1997 - National Acad Sciences
l-Asparaginyl and l-aspartyl residues in proteins are subject to spontaneous degradation
reactions that generate isomerized and racemized aspartyl derivatives. Proteins containing l-…

[PDF][PDF] Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir

…, E Bauer, C Parrish, DC MacLaren… - Journal of Nuclear …, 1998 - Soc Nuclear Med
We are developing procedures to repeatedly and noninvasively ¡ magethe expression of
transplanted reporter genes in living ani mals and in patients, using PET. We have …

PET imaging of transgene expression

DC MacLaren, T Toyokuni, SR Cherry, JR Barrio… - Biological …, 2000 - Elsevier
A vital step in transgenic animal study and gene therapy is the ability to assay the extent of
transgene expression. Unfortunately, classic methods of assaying transgene expression …

Seeing is believing: Non‐invasive, quantitative and repetitive imaging of reporter gene expression in living animals, using positron emission tomography

HR Herschman, DC MacLaren, M Iyer… - Journal of …, 2000 - Wiley Online Library
The ability to monitor reporter gene expression in living animals and in patients will permit
longitudinal examinations both of somatically transferred DNA in experimental animals and …

Relativistic corrections to reported sulfur 1s ionization energies

TX Carroll, D Ji, DC Maclaren, TD Thomas… - Journal of electron …, 1987 - Elsevier
Rapid communication RELATIVISTIC CORRECTIONS TO REPORTED SULFUR 1s
IONIZATION ENERGIES Sodhi and Cave11 [l] have recently report Page 1 Journal of …

Early exercise regimen improves insulin sensitivity in the intrauterine growth-restricted adult female rat offspring

…, SA Oak, G Pan, DC MacLaren… - American Journal …, 2009 - journals.physiology.org
We examined the effect of early exercise training (Ex) on glucose kinetics, basal, and insulin-stimulated
skeletal muscle (SKM) plasma membrane (PM) GLUT4 in pre- and/or postnatal …

Expression and purification of a human recombinant methyltransferase that repairs damaged proteins

DC MacLaren, S Clarke - Protein Expression and Purification, 1995 - Elsevier
We report the construction of a plasmid (pDM2x) containing the coding sequence of the more
acidic isozyme II of the human protein-L-isoaspartate (D-aspartate) O-methyltransferase (…

[HTML][HTML] Crystal structure of human L-isoaspartyl methyltransferase

…, SC Griffith, MR Sawaya, DC MacLaren… - Journal of Biological …, 2002 - ASBMB
The enzyme l-isoaspartyl methyltransferase initiates the repair of damaged proteins by
recognizing and methylating isomerized and racemized aspartyl residues in aging proteins. The …

Alternative splicing of the human isoaspartyl protein carboxyl methyltransferase RNA leads to the generation of a C-terminal-RDEL sequence in isozyme II

DC MacLaren, RM Kagan, S Clarke - Biochemical and biophysical …, 1992 - Elsevier
We have isolated two cDNA clones that correspond to the mRNAs for two isozymes of the
human l-isoaspartyl/d-aspartyl protein carboxyl methyltransferase (EC 2.1.1.77). The DNA …