CRISPR-Cas9 technologies have dramatically increased the ease of targeting DNA sequences
in the genomes of living systems. The fusion of chromatin-modifying domains to nuclease…

CRISPR-Cas9 transcriptional repressors have emerged as robust tools for disrupting gene
regulation in vitro but have not yet been adapted for systemic delivery in adult animal models. …

Human cytochrome P-450 (CYP)2J2 is abundant in heart and active in biosynthesis of
epoxyeicosatrienoic acids (EETs). Recently, we demonstrated that these eicosanoid products …

Nucleic acid binding polymers (NABPs) have been extensively used as vehicles for DNA and
RNA delivery. More recently, we discovered that a subset of these NABPs can also serve …

Purpose Diabetes is a grave and progressive condition characterized by debilitating
complications. Diabetic bladder dysfunction (DBD) is a very common complication with no specific …

Simple Summary Lymphovascular invasion (LVI), the presence of tumor cells in
lymphovascular spaces, is associated with an increased risk of metastasis and is considered an …

Intraarterial microdosing (IAM) is a novel drug development approach combining intraarterial
drug delivery and microdosing. We aimed to demonstrate that IAM leads to target exposure …

Purpose Tumor hypoxia contributes to aggressive phenotypes and diminished therapeutic
responses to radiation therapy (RT) with hypoxic tissue being 3-fold less radiosensitive than …

Background: Lymphovascular invasion (LVI) is a major route of metastatic dissemination and
recent studies indicate its value as an independent prognostic indicator for advanced breast…

… Douglas J Crouse … C 2017 by the American Bar Association. Reproduced i : ermi St si
ights reserved. Ths … Crouse is an attoney in the Environmental Practice Group atjaJckson …