ContextPreeclampsia is believed to result from release of placental factors that damage
maternal vascular endothelium. However, because most studies have been conducted during …

Sudden sensorineural hearing loss is usually unilateral and can be associated with tinnitus
and vertigo. In most cases the cause is not identified, although various infective, vascular, …

The regulation of blood vessel formation is of fundamental importance to many physiological
processes, and angiogenesis is a major area for novel therapeutic approaches to diseases …

Basic calcium phosphate (BCP) crystal deposition underlies the development of arterial
calcification. Inflammatory macrophages colocalize with BCP deposits in developing …

Intraplaque hemorrhage accelerates atherosclerosis via oxidant stress and contributes to
lesion development and destabilization. Normally, macrophages scavenge hemoglobin-…

Background—Although there is strong evidence that plasma HDL levels correlate inversely
with the incidence of coronary artery disease, the precise mechanism(s) for the protective …

Objective— Proinflammatory mediators influence atherosclerosis by inducing adhesion
molecules (eg, VCAM-1) on endothelial cells (ECs) via signaling intermediaries including p38 …

Background— Immunoglobulin M (IgM) natural antibodies bind oxidatively-modified low-density
lipoprotein (LDL) and apoptotic cells and have been implicated as being important for …

Tight regulation of the balance between apoptosis and survival is essential in angiogenesis.
The ETS transcription factor Erg is required for endothelial tube formation in vitro. Inhibition …

Transcription factors belonging to the NF-κB family regulate inflammation by inducing pro-inflammatory
molecules (eg interleukin (IL)-8) in response to cytokines (eg tumor necrosis …