Along with the great strides that have been made towards understanding cancer, has come
a realization of the complexity of molecular events that lead to malignancy. Proteomics-…

Using the polymerase chain reaction to study mRNA expressed in human epithelial tumor
cells, a member of a new family of protein kinases was identified. The catalytic domain of this …

The aim of this study was to evaluate the novel probe 18 F-6-fluoro-N-[2-(diethylamino)ethyl]
pyridine-3-carboxamide ( 18 F-MEL050) for the imaging of primary and metastatic …

Overexpression of the protein kinases mixed-lineage kinase-2 (MLK2) or mitogen-activated
protein kinase (MAPK) kinase kinase-1 (MEKK1) is known to trigger the activation of stress-…

The high melanoma uptake and rapid body clearance displayed by our series of [ 123 I]iodonicotinamides
prompted the development of [ 18 F]N-(2-(diethylamino)ethyl)-6-…

In vivo models that recapitulate oncogene-dependent tumorigenesis will greatly facilitate
development of molecularly targeted anticancer therapies. We have developed a model based …

Methods. Lysozyme activity was measured by lysis of a suspension of killed Micrococcus
lysodeikticus cells (Parry et al., 1965). A unit of enzyme activity is arbitrarily defined as the …

The efficacy of differing routes of administration of 18 F-6-fluoro-N-[2-(diethylamino)ethyl]
pyridine-3-carboxamide ( 18 F-MEL050), a new benzamide-based PET radiotracer for imaging …

The ability of PET to image functional changes in tumors is increasingly being used to
evaluate response and predict clinical benefit to conventional and novel cancer therapies. …

Protein kinases play pivotal roles in the control of many cellular processes. In a search for
protein kinases expressed in human epithelial tumour cells, we discovered two members of a …