Serial noninvasive targeted imaging of peripheral angiogenesis: validation and application of a semiautomated quantitative approach
…, DP Dione, L Kalinowski, D Dione… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Previous studies by our group have demonstrated the feasibility of noninvasive imaging of α
v integrin to assess temporal and spatial changes in peripheral and myocardial …
v integrin to assess temporal and spatial changes in peripheral and myocardial …
Quantification of in-vivo matrix metalloproteinase activity and myocardial strain yield unique spatial and temporal patterns in a porcine model of myocardial infarction
…, J Song, J McAteer, D Dione, L Dobrucki, D Dione… - 2006 - Am Heart Assoc
Background: Activation of matrix metalloproteinases (MMPs) contribute to left ventricular (LV)
remodeling post myocardial infarction (MI). Assessment of MMP activation has been limited …
remodeling post myocardial infarction (MI). Assessment of MMP activation has been limited …
Hybrid microSPECT-CT facilitates quantitative analysis of radiotracer-based images of peripheral angiogenesis
W Dobrucki, D Dione, L Kalinowski, D Dione… - 2007 - Soc Nuclear Med
565 Objectives: Previous studies by our group have demonstrated the feasibility of
noninvasive imaging of αv integrin to assess temporal and spatial changes in peripheral and …
noninvasive imaging of αv integrin to assess temporal and spatial changes in peripheral and …
MicroSPECT-CT Imaging Demonstrates Impairment of Matrix Metalloproteinases Activation in Ischemic Peripheral Angiogenesis in Type-1 Diabetes Associated with …
LW Dobrucki, D Dione, L Kalinowski, AJ Sinusas - 2008 - Am Heart Assoc
We previously demonstrated an impairment of ischemic peripheral angiogenesis (IPA) in a
murine model of hindlimb ischemia using a radiolabeled RGD peptide targeted at alpha-v …
murine model of hindlimb ischemia using a radiolabeled RGD peptide targeted at alpha-v …
Serial Quantification of Canine Post-Infarct Left Ventricular Remodeling Using a Novel Semi-Automated 3D Echo Speckle Tracking Algorithm
…, DP Dione, S Sampath, Z Zhang, D Dione… - 2012 - Am Heart Assoc
Background: Left ventricular (LV) remodeling after myocardial infarction (MI) is characterized
by infarct expansion, progressive LV dilation, and hypertrophy of non-infarct zones. Global …
by infarct expansion, progressive LV dilation, and hypertrophy of non-infarct zones. Global …
Insight on the chelation of aluminum (III) and iron (III) by curcumin in aqueous solution
In this work we have studied the complexation of curcumin (HCur, 1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione)
with Al(III) and Fe(III) at 37 C and in 0.16 M NaCl. The …
with Al(III) and Fe(III) at 37 C and in 0.16 M NaCl. The …
The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome
KF Petersen, S Dufour, DB Savage… - Proceedings of the …, 2007 - National Acad Sciences
We examined the hypothesis that insulin resistance in skeletal muscle promotes the development
of atherogenic dyslipidemia, associated with the metabolic syndrome, by altering the …
of atherogenic dyslipidemia, associated with the metabolic syndrome, by altering the …
Targeted imaging of the spatial and temporal variation of matrix metalloproteinase activity in a porcine model of postinfarct remodeling: relationship to myocardial …
…, J Song, J McAteer, RE Stroud, DP Dione… - Circulation …, 2011 - Am Heart Assoc
Background— Matrix metalloproteinases (MMPs) are known to modulate left ventricular (LV)
remodeling after a myocardial infarction (MI). However, the temporal and spatial variation of …
remodeling after a myocardial infarction (MI). However, the temporal and spatial variation of …
Stereoselective synthesis, biological evaluation, and modeling of novel bile acid-derived G-protein coupled bile acid receptor 1 (GP-BAR1, TGR5) agonists
… Conversion of these groups (CDCA) to ketones (5β-cholanic acid-3,7-dione) led to a sharp
decrease in activity (EC 50 of 10.93, Table 1), while introduction of a methyl group at the 23(S)…
decrease in activity (EC 50 of 10.93, Table 1), while introduction of a methyl group at the 23(S)…
… [5.2.0]non-1(7)-en-2-yl)- ethyl]phosphonic Acid (EAA-090), a Potent N-Methyl-d-aspartate Antagonist, via the Use of 3-Cyclobutene-1,2-dione as an Achiral α-Amino …
WA Kinney, M Abou-Gharbia, DT Garrison… - Journal of medicinal …, 1998 - ACS Publications
… -3-cyclobutene-1,2-dione group was described as a useful α-… -3-cyclobutene-1,2-dione group
has potential to be more … 3-cyclobutene-1,2-dione-containing substrate probably would not …
has potential to be more … 3-cyclobutene-1,2-dione-containing substrate probably would not …