Progesterone is a critical steroid hormone that controls cell proliferation and differentiation
in the female reproductive tract. Progesterone acts through two nuclear receptor isoforms, …

Endometrial carcinoma is the most common cancer of the female reproductive tract. GPER/GPR30
is a 7-transmembrane spanning G protein-coupled receptor that has been identified …

OBJECTIVE.: Hyperglycosylated hCG (hCG-H) is a glycosylation variant of hCG produced by
cytotrophoblast cells at implantation of pregnancy and in choriocarcinoma. We investigated …

Individual mutations in the tumor suppressor TP53 alter p53 protein function. Some mutations
create a non‑functional protein, whereas others confer oncogenic activity, which we term ‘…

Endometrial cancer, the most common gynecologic malignancy, is a hormonally-regulated
disease. Response to progestin therapy positively correlates with hormone receptor …

Objective. Nuclear factor kappa B (NFκB) is a strong anti-apoptotic factor, which is constitutively
active in human endometrial cancer cells. Progesterone is the principal growth inhibitory …

Progesterone, acting through its receptor, PR (progesterone receptor), is the natural inhibitor
of uterine endometrial carcinogenesis by inducing differentiation. PR is downregulated in …

The purpose of this study was to determine whether regression of the decidua basalis (DB),
which begins on Day 14 of pregnancy in the rat, results from an intrinsic program of …

OBJECTIVE: These studies were undertaken to characterize the subcellular localization of
the two major isoforms of progesterone receptors (PR), PRA and PRB, in endometrial cancer. …

OBJECTIVE: Endometrial tumors with non-functional p53, such as serous uterine endometrial
carcinomas, are aggressive malignancies with a poor outcome, yet they have an Achilles' …