Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral
mediator of liver regeneration. A 145-kilodalton tyrosyl phosphoprotein observed in rapid …

Multiple endocrine neoplasia types 2A and 2B (MEN2A and MEN2B) and familial medullary
thyroid carcinoma are dominantly inherited cancer syndromes. All three syndromes are …

Expression cDNA cloning and structural analysis of the human keratinocyte growth factor
receptor (KGFR) revealed identity with one of the fibroblast growth factor (FGF) receptors …

Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers
with different genetic drivers, clinical courses, and therapeutic responses. The current …

On binding to the cell surface receptor tyrosine kinase (TK) known as c-Met, hepatocyte growth
factor (HGF) stimulates mitogenesis, motogenesis, and morphogenesis in a wide range …

Purpose Foretinib is an oral multikinase inhibitor targeting MET, VEGF, RON, AXL, and TIE-2
receptors. Activating mutations or amplifications in MET have been described in patients …

Secreted Frizzled-related protein-1 (sFRP-1) contains a cysteine-rich domain homologous
to the putative Wnt-binding site of Frizzleds. To facilitate the biochemical and biological …

In an effort to isolate novel growth factors, we identified a human protein, designated Sk, that
co-eluted with Neuregulin during chromatographic separation of conditioned medium from …

On the basis of multidimensional and comprehensive molecular characterization (including
DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal …

A heparin-binding mitogen was isolated from conditioned medium of human embryonic lung
fibroblasts. It exhibited broad target-cell specificity whose pattern was distinct from that of …