MATERIALS AND METHODS Microanalyses were performed commercially. Thin layer
chromatography was done on precoated, 250-it silica gel plates. t The Cellex D anion-exchange …

We used a new radiopharmaceutical agent, [ 131 I]meta-iodobenzylguanidine ([ 131 I]MIBG),
to produce scintigraphic images of pheochromocytomas in eight patients. One day or more …

Meta-iodobenzylguanidine (M-IBG), an iodinated aromatic analog of the hypotensive drug
quanethidine, localizes in the heart of the rat, dog, and rhesus monkey. A comparative study …

To map presynaptic cholinergic terminal densities in normal aging (n = 36), Alzheimer's
disease (AD) (n = 22), and Parkinson's disease (PD) (n = 15), we performed single‐photon …

METHODS Iodine-l23 produced by the 1271 (p, 5n) †23Xe— 1231 reaction was obtained
commercially. t Meta-['231] io dobenzylguanidine (m-['231] IBG) was prepared by a method …

Background—Regional cardiac sympathetic hyperactivity predisposes to malignant arrhythmias
in nondiabetic cardiac disease. Conversely, however, cardiac sympathetic denervation …

The noninvasive functional characterization of the cardiac sympathetic nervous system by
imaging techniques may provide important pathophysiological information in various cardiac …

[11C] MHEDis synthesizedby directmethylationof metarami nol free basewith [11C]
methyliodidein DMF/DMSO (3: 1). After heatingfor 5 mm at 100ÂC, the reaction mixture was …

MATERIALS AND METHODS Patients. One or more tumors that were histologically typical
of pheochnomocytoma had been removed from each patient; de-differentiation of histology …

MATERIALS AND METHODS Synthesis of radioiodinated p-IBG and m-IBG. The synthesis
and determination of radiochemical purity of the radiolabeled compounds used in this study …