Background This study was designed to determine the incidence of thoracic bone infarction
in patients with sickle cell diseases who were hospitalized with acute chest or back pain …

The determinants of sickle red blood cell (RBC) life span have not been well-defined but
may include both intrinsic factors (eg, the tendency to sickle) and extrinsic factors (eg, the …

Phosphatidylserine (PS) is normally confined to the cytoplasmic leaflet of the red blood cell (RBC)
membrane, but some sickle RBCs expose PS in the outer leaflet (PS+ cells). This …

Four members of a Mennonite family, three of whom were first cousins, had asthma, nasal
polyps, and aspirin-induced wheezing (ASA triad). One of the cousins, whose husband was …

In 1945, Thomas Cooley described the first cases of X-linked sideroblastic anemia (XLSA)
in two brothers from a large family in which the inheritance of the disease was documented …

Sickle red blood cells (RBC) are subject to a number of important cellular changes and selection
pressures. In this study, we validated a biotin RBC label by comparison to the standard …

In the absence of evidence for pneumonia or pulmonary embolus, primary pulmonary infarction
has been assumed to be the cause of the syndrome of chest pain, fever, and pulmonary …

Sickle red blood cells (RBCs) become depleted of potassium, leading to dehydration and
abnormally elevated cellular density. The increased sickling that results is important for both …

Hemoglobin Wayne is an alpha chain variant which manifests itself as two minor hemoglobin
(Hb) components that migrate more rapidly than Hb A on electrophoresis at pH 8.6. It has …

The K+ efflux that mediates sickle-cell dehydration may occur through several pathways,
including two with a high capacity for mediating rapid K+ loss, KCl cotransport and the Ca(2+)-…