Pharmacological and biochemical criteria can be used to separate those dopamine
receptors which are linked to the enzyme adenylyl cyclase and those which are not.

Parkinson's disease (idiopathic parkinsonism or paralysis agitans) is characterized clinically
by progressive tremor, bradykinesia, and rigidity and pathologically by degeneration of the …

We have previously linked families with autosomal-dominant, late-onset parkinsonism to
chromosome 12p11.2-q13.1 (PARK8). By high-resolution recombination mapping and …

The power of placebos has long been recognized for improving numerous medical
conditions such as Parkinson's disease (PD). Little is known, however, about the mechanism …

Spinocerebellar ataxia type 2 (SCA2) has been recognized recently as an uncommon cause
of parkinsonism, an alternate presentation to the typical cerebellar disorder. This research …

Clinical symptoms of Parkinson's disease (PD) do not manifest until dopamine (DA)
neuronal loss reaches a symptomatic threshold. To explore the mechanisms of functional …

Parkinson's disease (PD) is a common degenerative neurologic disorder, which is pathologically
characterized by a selective degeneration of dopaminergic neurons of the substantia …

We studied the effect of botulinum‐A toxin on spasticity of the leg adductors in 9 patients who
were either chair‐bound or bed‐bound with chronic stable multiple sclerosis. We injected …

Clinical scales, based on the major signs of Parkinson's disease (PD), are commonly used to
assess the effect of symptomatic treatment of PD. With the appearance of therapy aiming to …

Peak-dose dyskinesias are abnormal movements that usually occur 1 h after oral
administration of levodopa, and often complicate chronic treatment of Parkinson's disease. We …