Emerging evidence has suggested that the capability of a tumor to grow and propagate is
dependent on a small subset of cells within a tumor, termed cancer stem cells. Although data …

Cellular heterogeneity in cancer was observed decades ago by studies in mice which
showed that distinct subpopulations of cells within a tumor mass are capable of driving …

There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection.
We investigated the proteomic profile of extracellular vesicles and particles (EVPs) in …

Single-cell RNA sequencing (scRNA-seq) enables the systematic identification of cell
populations in a tissue, but characterizing their spatial organization remains challenging. We …

Background & Aims Cancer stem cells (CSCs) can contribute to hepatocellular carcinoma (HCC)
progression and recurrence after therapy. The presence of tumor-associated …

Pancreatic ductal adenocarcinoma is an aggressive malignancy with a high mortality rate.
Proper determination of the extent of disease on imaging studies at the time of staging is one …

The molecular basis of pancreatic cancer is not understood. Previous attempts to determine
the specific genes expressed in pancreatic cancer have been hampered by similarities …

Despite tremendous gains in the molecular understanding of exocrine pancreatic cancer, the
prognosis for this disease remains very poor, largely because of delayed disease detection …

The spread of cancer throughout the body is driven by circulating tumour cells (CTCs) 1 .
These cells detach from the primary tumour and move from the bloodstream to a new site of …

Recent observations indicate that, in several types of human cancer, only a phenotypic
subset of cancer cells within each tumor is capable of initiating tumor growth. This functional …