User profiles for Detlev Boison

Detlev Boison

Dept. of Neurosurgery, Rutgers Robert Wood Johnson Medical School
Verified email at rutgers.edu
Cited by 16230

[HTML][HTML] A ketogenic diet suppresses seizures in mice through adenosine A1 receptors

…, JD Geiger, E Aronica, D Boison - The Journal of …, 2011 - Am Soc Clin Investig
Many individuals with epilepsy benefit from consuming a ketogenic diet, which is similar to
the more commonly known Atkins diet. The underlying molecular reason for this has not been …

[HTML][HTML] Adenosine signaling and function in glial cells

D Boison, JF Chen, BB Fredholm - Cell Death & Differentiation, 2010 - nature.com
Despite major advances in a variety of neuroscientific research fields, the majority of
neurodegenerative and neurological diseases are poorly controlled by currently available drugs, …

Adenosine kinase, epilepsy and stroke: mechanisms and therapies

D Boison - Trends in pharmacological sciences, 2006 - cell.com
Adenosine is an inhibitory modulator of brain activity with neuroprotective and anticonvulsant
properties. Adenosine levels are regulated mainly by adenosine kinase (ADK), an enzyme …

[HTML][HTML] Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis

…, EM Pritchard, DL Kaplan, D Boison - The Journal of …, 2013 - Am Soc Clin Investig
Epigenetic modifications, including changes in DNA methylation, lead to altered gene
expression and thus may underlie epileptogenesis via induction of permanent changes in …

Adenosine kinase: exploitation for therapeutic gain

D Boison - Pharmacological reviews, 2013 - ASPET
Adenosine kinase (ADK; EC 2.7.1.20) is an evolutionarily conserved phosphotransferase
that converts the purine ribonucleoside adenosine into 5′-adenosine-monophosphate. This …

The concise guide to pharmacology 2019/20: Enzymes

…, A Beuve, D Boison… - British Journal of …, 2019 - Wiley Online Library
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial
publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 …

New insights into the mechanisms of the ketogenic diet

D Boison - Current opinion in neurology, 2017 - journals.lww.com
… Correspondence to Detlev Boison, PhD, Robert Stone Dow Neurobiology Laboratories,
Legacy Research Institute, 1225 NE 2nd Ave, Portland, OR 97232, USA. Tel: +1 503 413 …

The concise guide to pharmacology 2021/22: Enzymes

…, JA Davies, S Annett, D Boison… - British journal of …, 2021 - Wiley Online Library
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key …

Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens

…, K Semba, BB Fredholm, D Boison… - Journal of …, 2011 - Soc Neuroscience
Caffeine, the most widely used psychoactive compound, is an adenosine receptor antagonist.
It promotes wakefulness by blocking adenosine A 2A receptors (A 2A Rs) in the brain, but …

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

…, E Aronica, C Bernard, I Blümcke, D Boison… - …, 2018 - Wiley Online Library
The most common forms of acquired epilepsies arise following acute brain insults such as
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for …