OBJECTIVE: Most research on the effects of severe psychological stress has focused on
stress-related psychopathology. Here, the author develops psychobiological models of …

Background: A growing body of preclinical research suggests that brain glutamate systems
may be involved in the pathophysiology of major depression and the mechanism of action of …

The limited success of genetic studies of major depression has raised questions concerning
the definition of genetically relevant phenotypes. This paper presents strategies to improve …

Humans exhibit a remarkable degree of resilience in the face of extreme stress, with most
resisting the development of neuropsychiatric disorders. Over the past 5 years, there has been …

• The Yale-Brown Obsessive Compulsive Scale was designed to remedy the problems of
existing rating scales by providing a specific measure of the severity of symptoms of …

Every individual experiences stressful life events. In some cases acute or chronic stress leads
to depression and other psychiatric disorders, but most people are resilient to such effects. …

Several interviews are available for assessing PTSD. These interviews vary in merit when
compared on stringent psychometric and utility standards. Of all the interviews, the Clinician-…

• The development design and reliability of the Yale-Brown Obsessive Compulsive Scale
have been described elsewhere. We focused on the validity of the Yale-Brown Scale and its …

Background: To characterize further behavioral, cognitive, neuroendocrine, and physiological
effects of subanesthetic doses of ketamine hydrochloride in healthy human subjects. …

Context Existing therapies for major depression have a lag of onset of action of several weeks,
resulting in considerable morbidity. Exploring pharmacological strategies that have rapid …