Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues

M Stoeckli, P Chaurand, DE Hallahan, RM Caprioli - Nature medicine, 2001 - nature.com
Fig. 1 Methodology developed for the spatial analysis of tissue by MALDI mass spectrometry.
Frozen sections are mounted on a metal plate, coated with an UV-absorbing matrix and …

Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation.

DE Hallahan, DR Spriggs, MA Beckett… - Proceedings of the …, 1989 - National Acad Sciences
We report that tumor necrosis factor alpha (TNF-alpha) mRNA is increased after treatment
with x-rays in certain human sarcoma cells. An increase in TNF-alpha mRNA is accompanied …

Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy

…, PC Lin, E Sierra-Rivera, H Oshinka, DE Hallahan - Cancer research, 2001 - AACR
Certain refractory neoplasms, such as glioblastoma multiforme (GBM) and melanoma,
demonstrate a resistant tumor phenotype in vivo. We observed that these refractory tumor models (…

Phase I/II trial of electrophysiology-guided noninvasive cardiac radioablation for ventricular tachycardia

…, TW Smith, PK Woodard, RJ Gropler, DE Hallahan… - Circulation, 2019 - Am Heart Assoc
Background: Case studies have suggested the efficacy of catheter-free, electrophysiology-guided
noninvasive cardiac radioablation for ventricular tachycardia (VT) using stereotactic …

Spatial and temporal control of gene therapy using ionizing radiation

DE Hallahan, HJ Mauceri, LP Seung, EJ Dunphy… - Nature medicine, 1995 - nature.com
Activation of transcription of the Egr-1 gene by X-rays is regulated by the promoter region of
this gene. We linked the radiation-inducible promoter region of the Egr-1 gene to the gene …

SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models

…, E Donnelly, D Mendel, G McMahon, DE Hallahan - Cancer research, 2003 - AACR
Receptor tyrosine kinase activation contributes to cell viability during cytotoxic therapy. The
novel broad spectrum receptor tyrosine kinase inhibitor, SU11248, inhibits vascular …

[HTML][HTML] GSK-3 𝜷: A Bifunctional Role in Cell Death Pathways

…, DJ Ferraro, JJ Jaboin, DE Hallahan… - International journal of …, 2012 - hindawi.com
Although glycogen synthase kinase-3 beta (GSK-3β) was originally named for its ability to
phosphorylate glycogen synthase and regulate glucose metabolism, this multifunctional …

A study on adaptive IMRT treatment planning using kV cone-beam CT

…, CW Coffey, M Deeley, DE Hallahan… - Radiotherapy and …, 2007 - Elsevier
BACKGROUND AND PURPOSE: Changes in tumor size during the course of radiotherapy
warrant performing adaptive radiotherapy (ART). This work investigates the feasibility and …

Inhibition of αvβ3 Integrin Survival Signaling Enhances Antiangiogenic and Antitumor Effects of Radiotherapy

…, KE Lipson, R Saffrich, HJ Gröne, DE Hallahan… - Clinical cancer …, 2005 - AACR
The involvement of α v β 3 and α v β 5 integrins in angiogenesis and the use of integrin
antagonists as effective antiangiogenic agents are documented. Radiotherapy is an important …

Lithium treatment prevents neurocognitive deficit resulting from cranial irradiation

…, WO Whetsell Jr, B Boone, ET Shinohara, DE Hallahan - Cancer research, 2006 - AACR
Curative cancer treatment regimens often require cranial irradiation, resulting in lifelong
neurocognitive deficiency in cancer survivors. This deficiency is in part related to radiation-…