Microwave enhanced greener synthesis of indazoles via nitrenes

DJ Varughese, MS Manhas, AK Bose - Tetrahedron letters, 2006 - Elsevier
Non-traditional methods (grinding, water-based biphasic reactions, microwave chemistry)
were used for the preparation of Schiff bases from several amines and 2-nitrobenzaldehydes. …

Low‐energy collision‐induced fragmentation of negative ions derived from ortho‐, meta‐, and para‐hydroxyphenyl carbaldehydes, ketones, and related compounds

AB Attygalle, J Ruzicka, D Varughese… - Journal of mass …, 2007 - Wiley Online Library
Collision‐induced dissociation (CID) mass spectra of anions derived from several
hydroxyphenyl carbaldehydes and ketones were recorded and mechanistically rationalized. For …

Total synthesis of Resolvin E1

…, R Krishnamoorthy, C Manley, S Steffke, D Varughese… - Tetrahedron letters, 2011 - Elsevier
The enantioselective total synthesis of Resolvin E1 (RvE1), a naturally occurring small
molecule mediator of inflammation resolution, is reported. Two routes are presented, both …

Aminopiperidine Sulfonamide Cav2.2 Channel Inhibitors for the Treatment of Chronic Pain

…, F Ye, PK Chakravarty, DJ Varughese… - Journal of medicinal …, 2012 - ACS Publications
The voltage-gated calcium channel Ca v 2.2 (N-type calcium channel) is a critical regulator
of synaptic transmission and has emerged as an attractive target for the treatment of chronic …

[PDF][PDF] An unprecedented ortho effect in mass spectrometric fragmentation of even-electron negative ions from hydroxyphenyl carbaldehydes and ketones

A Attygalle, J Ruzicka, D Varughese, J Sayed - Tetrahedron letters, 2006 - academia.edu
A mass spectrometric peak for a carboxylate anion is observed in collision-induced
dissociation (CID) mass spectra recorded from negative ions derived from ortho isomers of …

Prospective Randomized Placebo-Controlled Trial of Long-Term Durability of Effect of One Year of Grape Consumption on Stabilizing Brain Metabolism in Patients …

J Lu, S Liu, A Alcantara, D Varughese, D Silverman - 2023 - Soc Nuclear Med
P1270 Introduction: We recently reported that grape consumption over one year in a prospective,
randomized, double-blind placebo-controlled study of people experiencing cognitive …

Prospective Randomized Placebo‐Controlled Trial of Long‐Term Durability of Effect of One Year of Grape Consumption on Preventing Decline of Cerebral Function

…, JL Lu, AR Alcantara, DV Varughese… - Alzheimer's & …, 2023 - Wiley Online Library
Background Long‐term impact of one year of grape consumption on regional brain metabolism
and associated neuropsychologic status was examined across multiple years of follow‐…

Examining Long-Term Impact of Grape Consumption on Brain Metabolism in Patients with Mild Decline in Cognition: a Double-Blind Placebo-Controlled Longitudinal …

J Lu, A Alcantara, S Liu, D Varughese, D Silverman - 2021 - Soc Nuclear Med
1084 Objectives: We previously reported that grape consumption by people experiencing
decline in cognition leads to the preservation of metabolism in brain regions important to …

Examining the impact of grape consumption on brain metabolism in patients with mild decline in cognition: A double-blinded placebo controlled expansion study

J Lu, A Alcantara, S Liu, D Varughese, D Silverman - 2020 - Soc Nuclear Med
1540 Objectives: We previously reported that grape consumption by people experiencing
decline in cognition leads to the preservation of metabolism in brain regions important to …

General Anesthesia and Cerebral Function: Changes in Cognition and Regional Brain Metabolism in Patients following Surgery

H Struble, S Liu, D Varughese, D Silverman - 2022 - Soc Nuclear Med
2422 Introduction: While the relationship between exposure to general anesthesia and
subsequent development of dementia has been investigated in prior literature, the specific …