BACKGROUND: Depression will be the second largest cause of disease burden by 2020. It
is commonly associated with long term physical health conditions resulting in worsened …

In patients with diabetes mellitus, hemoglobin A 1c (A1C) is commonly interpreted as a
measure of long‐term glycemic control, reflecting a mean glucose level over the previous 2–3 …

Inducible nitric oxide synthase (iNOS) activity increases in acute and chronic inflammatory
lung diseases. Imaging iNOS expression may be useful as an inflammation biomarker for …

Objective: To review the efficacy and safety of off-label use of modafinil in the treatment of
multiple sclerosis (MS)–related fatigue. Data Sources: Literature was accessed via MEDLINE (…

The layered learning practice model (LLPM) is a teaching strategy designed to train residents
to precept students and other residents with the oversight of a seasoned clinical pharmacist…

The Fontan operation is a common end point for children born with a single functional ventricle.
Fontan patients typically experience physiological deterioration leading to transplant or …

Background Depression is a common, debilitating and costly disorder. The best-evidenced
psychological therapy-cognitive-behavioural therapy (CBT)-is complex and costly. A simpler …

Legal and cultural clashes occur when international conventions dictate the adoption of
new legal constructs into domestic law.'This happened recently when the World Trade …

Background Anti-inflammatory drug development efforts for lung disease have been
hampered in part by the lack of noninvasive inflammation biomarkers and the limited ability of …

Software for micro or personal computers is commonly mass marketed by mail order, over
the counter, or as an optional package available with the purchase of hardware.'Mass …