Imaging of HER2/neu-positive BT-474 human breast cancer xenografts in athymic mice using 111In-trastuzumab (Herceptin) Fab fragments
Y Tang, J Wang, DA Scollard, H Mondal… - Nuclear medicine and …, 2005 - Elsevier
Trastuzumab (Herceptin) Fab were prepared by digestion of intact IgG with immobilized papain,
derivatized with diethylenetriaminepentaacetic acid (DTPA) and radiolabeled with 111 In…
derivatized with diethylenetriaminepentaacetic acid (DTPA) and radiolabeled with 111 In…
Associations between the uptake of 111In-DTPA-trastuzumab, HER2 density and response to trastuzumab (Herceptin) in athymic mice bearing subcutaneous human …
K McLarty, B Cornelissen, DA Scollard, SJ Done… - European journal of …, 2009 - Springer
Purpose The purpose of the study was to investigate the associations between uptake of 111
In-DTPA-trastuzumab, tumour HER2 density and response to trastuzumab (Herceptin) of …
In-DTPA-trastuzumab, tumour HER2 density and response to trastuzumab (Herceptin) of …
Role of antibody-mediated tumor targeting and route of administration in nanoparticle tumor accumulation in vivo
In this study, we have looked at enhancing tumor uptake and intracellular delivery of gold
nanoparticles (AuNPs) while reducing the systemic exposure by systematic evaluation of the …
nanoparticles (AuNPs) while reducing the systemic exposure by systematic evaluation of the …
Micro-SPECT/CT with 111In-DTPA-pertuzumab sensitively detects trastuzumab-mediated HER2 downregulation and tumor response in athymic mice bearing MDA …
…, B Cornelissen, Z Cai, DA Scollard… - Journal of Nuclear …, 2009 - Soc Nuclear Med
… McLarty K, Cornelissen B, Scollard D, Done S, Chun K, Reilly R. Associations between
the uptake of 111 In-DTPA-trastuzumab, HER2 density and response to trastuzumab (Herceptin) …
the uptake of 111 In-DTPA-trastuzumab, HER2 density and response to trastuzumab (Herceptin) …
[HTML][HTML] Phase I trial to evaluate the tumor and normal tissue uptake, radiation dosimetry and safety of 111In-DTPA-human epidermal growth factor in patients with …
KA Vallis, RM Reilly, D Scollard, P Merante… - American journal of …, 2014 - ncbi.nlm.nih.gov
The safety, pharmacokinetics, biodistribution and radiation dosimetry of 111 In-DTPA-hEGF,
an Auger electron-emitting radiopharmaceutical, were evaluated in a first-in-human trial. …
an Auger electron-emitting radiopharmaceutical, were evaluated in a first-in-human trial. …
[HTML][HTML] Oncolytic vaccinia virus expressing the human somatostatin receptor SSTR2: molecular imaging after systemic delivery using 111In-pentetreotide
JA McCart, N Mehta, D Scollard, RM Reilly… - Molecular Therapy, 2004 - cell.com
Oncolytic vaccinia viruses (VV) have demonstrated tumor specificity, high levels of
transgene expression, and anti-tumor effects. The ability to visualize vector biodistribution …
transgene expression, and anti-tumor effects. The ability to visualize vector biodistribution …
In vitro and in vivo evaluation of WK‐X‐34, a novel inhibitor of P‐glycoprotein and BCRP, using radio imaging techniques
V Jekerle, W Klinkhammer, DA Scollard… - … journal of cancer, 2006 - Wiley Online Library
Overexpression of the multidrug resistance proteins P‐glycoprotein (Pgp) and breast cancer
resistance protein (BCRP) results in treatment failure of many malignancies including …
resistance protein (BCRP) results in treatment failure of many malignancies including …
Preclinical pharmacokinetic, biodistribution, toxicology, and dosimetry studies of 111In-DTPA-human epidermal growth factor: an auger electron–emitting …
RM Reilly, P Chen, J Wang, D Scollard… - Journal of Nuclear …, 2006 - Soc Nuclear Med
Our objective was to evaluate the pharmacokinetics, normal tissue distribution, radiation
dosimetry, and toxicology of human epidermal growth factor (hEGF) labeled with 111 In ( 111 In-…
dosimetry, and toxicology of human epidermal growth factor (hEGF) labeled with 111 In ( 111 In-…
Relationship between induction of phosphorylated H2AX and survival in breast cancer cells exposed to 111In-DTPA-hEGF
Z Cai, Z Chen, KE Bailey, DA Scollard… - Journal of Nuclear …, 2008 - Soc Nuclear Med
The Auger electron–emitting radiopharmaceutical 111 In-diethylenetriaminepentaacetic
acid human epidermal growth factor ( 111 In-DTPA-hEGF) binds the epidermal growth factor …
acid human epidermal growth factor ( 111 In-DTPA-hEGF) binds the epidermal growth factor …
Imaging of HER2/neu expression in BT-474 human breast cancer xenografts in athymic mice using [99mTc]-HYNIC-trastuzumab (Herceptin) Fab fragments
Y Tang, D Scollard, P Chen, J Wang… - Nuclear medicine …, 2005 - journals.lww.com
Objective To evaluate the ability of trastuzumab (Herceptin) Fab, labelled with 99m Tc
through introduced hydrazinenicotinamide (HYNIC) functionalities, to image HER2/neu-…
through introduced hydrazinenicotinamide (HYNIC) functionalities, to image HER2/neu-…