Imaging of HER2/neu-positive BT-474 human breast cancer xenografts in athymic mice using 111In-trastuzumab (Herceptin) Fab fragments
Y Tang, J Wang, DA Scollard, H Mondal… - Nuclear medicine and …, 2005 - Elsevier
Trastuzumab (Herceptin) Fab were prepared by digestion of intact IgG with immobilized papain,
derivatized with diethylenetriaminepentaacetic acid (DTPA) and radiolabeled with 111 In…
derivatized with diethylenetriaminepentaacetic acid (DTPA) and radiolabeled with 111 In…
Associations between the uptake of 111In-DTPA-trastuzumab, HER2 density and response to trastuzumab (Herceptin) in athymic mice bearing subcutaneous human …
K McLarty, B Cornelissen, DA Scollard, SJ Done… - European journal of …, 2009 - Springer
Purpose The purpose of the study was to investigate the associations between uptake of 111
In-DTPA-trastuzumab, tumour HER2 density and response to trastuzumab (Herceptin) of …
In-DTPA-trastuzumab, tumour HER2 density and response to trastuzumab (Herceptin) of …
Micro-SPECT/CT with 111In-DTPA-pertuzumab sensitively detects trastuzumab-mediated HER2 downregulation and tumor response in athymic mice bearing MDA …
…, B Cornelissen, Z Cai, DA Scollard… - Journal of Nuclear …, 2009 - Soc Nuclear Med
… McLarty K, Cornelissen B, Scollard D, Done S, Chun K, Reilly R. Associations between
the uptake of 111 In-DTPA-trastuzumab, HER2 density and response to trastuzumab (Herceptin) …
the uptake of 111 In-DTPA-trastuzumab, HER2 density and response to trastuzumab (Herceptin) …
In vitro and in vivo evaluation of WK‐X‐34, a novel inhibitor of P‐glycoprotein and BCRP, using radio imaging techniques
V Jekerle, W Klinkhammer, DA Scollard… - … journal of cancer, 2006 - Wiley Online Library
Overexpression of the multidrug resistance proteins P‐glycoprotein (Pgp) and breast cancer
resistance protein (BCRP) results in treatment failure of many malignancies including …
resistance protein (BCRP) results in treatment failure of many malignancies including …
Relationship between induction of phosphorylated H2AX and survival in breast cancer cells exposed to 111In-DTPA-hEGF
Z Cai, Z Chen, KE Bailey, DA Scollard… - Journal of Nuclear …, 2008 - Soc Nuclear Med
The Auger electron–emitting radiopharmaceutical 111 In-diethylenetriaminepentaacetic
acid human epidermal growth factor ( 111 In-DTPA-hEGF) binds the epidermal growth factor …
acid human epidermal growth factor ( 111 In-DTPA-hEGF) binds the epidermal growth factor …
Detection of P-glycoprotein activity in endotoxemic rats by 99mTc-sestamibi imaging
99m Tc-sestamibi is a widely used radiopharmaceutical agent for myocardial and oncologic
imaging. Because of its unique role as a P-glycoprotein (Pgp)–specific substrate, this …
imaging. Because of its unique role as a P-glycoprotein (Pgp)–specific substrate, this …
64Cu-Labeled Trastuzumab Fab-PEG24-EGF Radioimmunoconjugates Bispecific for HER2 and EGFR: Pharmacokinetics, Biodistribution, and Tumor Imaging by …
LY Kwon, DA Scollard, RM Reilly - Molecular pharmaceutics, 2017 - ACS Publications
Heterodimerization of EGFR with HER2 coexpressed in breast cancer (BC) promotes tumor
growth, and increased EGFR expression is associated with trastuzumab resistance. Our aim …
growth, and increased EGFR expression is associated with trastuzumab resistance. Our aim …
123I-labeled HIV-1 tat peptide radioimmunoconjugates are imported into the nucleus of human breast cancer cells and functionally interact in vitro and in vivo with the cyclin …
M Hu, P Chen, J Wang, DA Scollard, KA Vallis… - European journal of …, 2007 - Springer
123I-labeled HIV-1 tat peptide radioimmunoconjugates are imported into the nucleus of
human breast cancer cells and functionally interact in vitro and in vivo with the cyclin-dependent …
human breast cancer cells and functionally interact in vitro and in vivo with the cyclin-dependent …
A human transferrin-vascular endothelial growth factor (hnTf-VEGF) fusion protein containing an integrated binding site for 111In for imaging tumor angiogenesis
C Chan, J Sandhu, A Guha, DA Scollard… - Journal of Nuclear …, 2005 - Soc Nuclear Med
Our objective was to synthesize a recombinant protein (hnTf-VEGF [VEGF is vascular
endothelial growth factor]) composed of VEGF 165 fused through a flexible polypeptide linker (…
endothelial growth factor]) composed of VEGF 165 fused through a flexible polypeptide linker (…
Epidermal growth factor receptor inhibition modulates the nuclear localization and cytotoxicity of the Auger electron–emitting radiopharmaceutical 111In-DTPA …
…, DL Costantini, Z Cai, DA Scollard… - Journal of Nuclear …, 2007 - Soc Nuclear Med
111 In-DTPA–human epidermal growth factor ( 111 In-DTPA-hEGF [DTPA is
diethylenetriaminepentaacetic acid]) is an Auger electron–emitting radiopharmaceutical that targets …
diethylenetriaminepentaacetic acid]) is an Auger electron–emitting radiopharmaceutical that targets …