A combined genome-wide association and linkage study was used to identify loci causing
variation in cystic fibrosis lung disease severity. We identified a significant association (P = …

From transcription to translation, mRNA is complexed with heterogeneous nuclear
ribonucleoproteins (hnRNP proteins) that mediate mRNA processing, export from the nucleus, and …

For mRNA to be transported from the nucleus to the cytoplasm, it must travel from the site of
transcription through the nuclear interior to the nuclear pore. Studies in Saccharomyces …

Background Progressive lung disease accounts for the majority of morbidity and mortality
observed in cystic fibrosis (CF). Beyond secondhand smoke exposure and socio-economic …

Background Lung infection by various organisms is a characteristic feature of cystic fibrosis (CF).
CFTR genotype effects acquisition of Pseudomonas aeruginosa (Pa), however the …

This article develops an empirical measure of public entrepreneurship and uses it to discover
the correlates that distinguish between those participants in a policy domain who are seen …

Rationale: Individuals with cystic fibrosis (CF) are subject to recurrent respiratory infections (exacerbations)
that often require intravenous antibiotic treatment and may result in …

OBJECTIVES: To determine the prevalence of vitamin D deficiency (25-hydroxy vitamin D [25-OHD]
levels in plasma <30 ng/mL) in pediatric patients with cystic fibrosis (CF), elucidate …

Mature poly(A) RNA transcripts are exported from the nucleus in complex with
heterogeneous nuclear ribonucleoproteins (hnRNPs). Nab2p is an essential Saccharomyces …

Background Cystic fibrosis (CF) is caused by mutations in the CFTR gene that predispose
the airway to infection. Chronic infection by pathogens such as Pseudomonas aeruginosa …