We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes.
HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have …

Rationale: Cardiovascular disease represents a global pandemic. The advent of and recent
advances in mouse genomics, epigenomics, and transgenics offer ever-greater potential for …

This paper is the third in a series of reviews published in this issue resulting from the
University of California Davis Cardiovascular Symposium 2014: Systems approach to …

Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix
in the heart, providing support to the contracting myocardium and contributing to a myriad of …

Aims Emipagliflozin (EMPA) is a potent inhibitor of the renal sodium-glucose co-transporter
2 (SGLT2) and an effective treatment for type-2 diabetes. In patients with diabetes and heart …

Chronic kidney disease (CKD) is a complex condition with a prevalence of 10–15% worldwide.
An inverse-graded relationship exists between cardiovascular events and mortality with …

Background : Antiarrhythmic drugs are widely used to treat patients with atrial fibrillation (AF),
but the mechanisms conveying their variable effectiveness are not known. Recent data …

BACKGROUND Genomic and experimental studies suggest a role for PITX2 in atrial
fibrillation (AF). To assess if this association is relevant for recurrent AF in patients, we tested …

The ability to record and analyse electrical behaviour across the heart using optical and
electrode mapping has revolutionised cardiac research. However, wider uptake of these …

As the only quantitatively significant Na efflux pathway from cardiac cells, the Na/K ATPase (Na
pump) is the primary regulator of intracellular Na. The transmembrane Na gradient it …